The ever-expanding role of HIF in tumour and stromal biology.
The ever-expanding role of HIF in tumour and stromal biology.
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DOI：
10.1038/ncb3330
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发表时间：
2016-04
影响因子：
21.3
通讯作者：
Giaccia AJ
中科院分区：
文献类型：
--
作者：
LaGory EL;Giaccia AJ
低氧张力（缺氧）是影响癌细胞功能的癌症标志，但也是肿瘤微环境的重要组成部分，因为它改变细胞外基质，调节肿瘤免疫反应并增加血管生成。在这里，我们讨论的调节和缺氧及其关键的转录介质，缺氧诱导因子（HIF）家族的转录因子，在肿瘤微环境和基质隔室的作用。
Low oxygen tension (hypoxia) is a hallmark of cancer that influences cancer cell function, but is also an important component of the tumour microenvironment as it alters the extracellular matrix, modulates the tumour-immune response and increases angiogenesis. Here we discuss the regulation and role of hypoxia and its key transcriptional mediators, the hypoxia inducible factor (HIF) family of transcription factors, in the tumour microenvironment and stromal compartments.