Identifying methadone maintenance clients at risk for poor treatment response: pretreatment and early progress indicators
Identifying methadone maintenance clients at risk for poor treatment response: pretreatment and early progress indicators
复制标题
DOI：
10.1016/s0376-8716(98)00176-8
复制
发表时间：
1999-06-01
影响因子：
4.2
通讯作者：
Iguchi, MY
中科院分区：
文献类型：
--
作者：
Morral, AR;Belding, MA;Iguchi, MY
详尽的研究发现，很少有人口统计学或其他预处理因素可以可靠地预测药物滥用治疗的表现。在这项研究中，我们评估了早期治疗反应是否能更好地预测6个月和9个月后的治疗反应。新入院接受美沙酮维持治疗（n = 59）的患者在入院后6个月和9个月的尿液分析结果显示，根据治疗保留和持续用药情况将其分为结局组。回归分析显示，两项早期（第2周）绩效指标，咨询出席率和阿片类药物戒断，可用于正确分类超过80%的样本结果。引人注目的是，在第2周既没有提交阿片类药物阴性尿样，也没有参加至少两次预定咨询会议的20名参与者中，没有一个人在6个月后取得了更好的结果。对于那些在第2周提交了两次阿片类药物阴性尿样并参加了两次咨询会议的人来说，获得良好结果的几率大大增加。因此，第2周的治疗表现可以很好地预测6个月的预后。第9个月的结果也报告了类似的结果。1999爱思唯尔科学爱尔兰有限公司版权所有。
Exhaustive searches have uncovered few demographic or other pretreatment factors that reliably predict performance in substance abuse treatments. In this study we evaluate whether early treatment response offers improved prediction of treatment response 6 and 9 months later. New admissions to methadone maintenance treatment (n = 59) were dichotomized into outcome groups based on treatment retention and ongoing drug use as revealed by urinalysis results 6 and 9 months after admission. Regression analyses revealed two early (week 2) performance measures, counseling attendance and opiate abstinence, could be used to correctly classify the outcomes of more than 80% of the sample. Strikingly, of the 20 participants who neither submitted an opiate-negative urine sample in week 2 nor attended at least two scheduled counseling sessions by that time, not one achieved a superior 6-month outcome. The odds of having a superior outcome increased considerably for those who submitted two opiate negative urine samples and attended two counseling sessions by week 2. Thus, 6-month outcomes were well predicted by treatment performance in week 2. Similar results are reported for month 9 outcomes. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.