Colorimetric detection of mercuric ion (Hg2+) in aqueous media using DNA-functionalized gold nanoparticles
Colorimetric detection of mercuric ion (Hg2+) in aqueous media using DNA-functionalized gold nanoparticles
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DOI：
10.1002/anie.200700269
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发表时间：
2007-01-01
影响因子：
16.6
通讯作者：
Mirkin, Chad A.
中科院分区：
文献类型：
--
作者：
Lee, Jae-Seung;Han, Min Su;Mirkin, Chad A.
颜色就是一切：Hg 2+在水介质中通过胸苷-Hg 2+-胸苷配位复合物的形成来检测，该复合物提高了DNA杂交的金纳米颗粒探针的熔化温度，从而提高了探针分散并产生紫红色变化的温度。该方法具有非常高的灵敏度和选择性，并提供了一个简单而快速的比色读数（见图）。（图为）
Color is everything: Hg 2+ in aqueous media is detected by the formation of thymidine-Hg 2+-thymidine coordination complexes, which raises the melting temperature of the DNA-hybridized gold nanoparticle probes and thus the temperature at which the probes disperse and effect a purple-to-red color change. The method has very high sensitivity and selectivity, and it provides a simple and fast colorimetric readout (see picture).(Figure Presented)