Cardiovascular magnetic resonance-derived myocardial strain in asymptomatic heart transplanted patients and its correlation with late gadolinium enhancement
Cardiovascular magnetic resonance-derived myocardial strain in asymptomatic heart transplanted patients and its correlation with late gadolinium enhancement
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无症状心脏移植患者心血管磁共振心肌应变及其与晚期钆增强的相关性
DOI：
10.1007/s00330-020-06763-3
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发表时间：
2020
影响因子：
5.9
通讯作者：
Liang Bo
中科院分区：
文献类型：
--
作者：
Shen Xuehua;Yuan Yating;Yang Ming;Wang Jing;Sun Wei;Xie Mingxing;Zhang Li;Zhou Xiaoyue;Liang Bo
目的探讨左心室射血分数(LVEF)正常的无症状心脏移植(HT)患者是否存在心血管磁共振(CMR)心肌应变异常，以及CMR心肌应变参数与晚期Gd增强(LGE)的关系。方法72例HT患者和35例健康志愿者接受1.5T磁共振扫描。检查方案包括基础电影成像和LGE。应变分析采用形变配准算法(DRA)和特征跟踪(FT)软件。心肌应变测量包括左心室整体纵向应变、左心室整体周向应变、左心室整体径向应变和右室纵向应变。结果与健康志愿者相比，高血压患者左、右室轴向应变显著降低(P<0.0 5)，左、右室轴向应变无明显差异(P>0.0 5)。DRA和FT得到的应变参数之间有显著的相关性和高度的重复性。CMR测量的LVGLS和LVGRS均与LGE的存在显著相关，多因素Logistic回归分析显示，两种技术测量的LVGLS与LGE的存在独立相关。DRA-LVGLS和FT-LVGLS的优势比(OR)分别为1.340和1.342。左心室射血分数(LVEF)正常的无症状心脏移植(HT)患者的心肌应变参数降低。·无症状HT患者的形变配准算法(DRA)和特征跟踪(FT)派生的应变具有很高的重复性。·DRA和FT派生的LVGLS与无症状HT患者的晚期Gd增强(LGE)独立相关。
ObjectivesTo investigate whether cardiovascular magnetic resonance (CMR)–derived myocardial strains were abnormal in asymptomatic heart transplant (HT) patients with normal left ventricular ejection fraction (LVEF) and to detect the relationship between CMR-derived myocardial strain parameters and late gadolinium enhancement (LGE) in asymptomatic HT patients.MethodsA total of 72 HT patients and 35 healthy volunteers underwent 1.5-T MR scanning. The examination protocol included basic cine imaging and LGE. The deformation registration algorithm (DRA) and feature tracking (FT) software were used for the strain analyses. Myocardial strain measurements included left ventricular global longitudinal strain (LVGLS), LV global circumferential strain (LVGCS), LV global radial strain (LVGRS) and right ventricular longitudinal strain (RVLS).ResultsCompared with healthy volunteers, HT patients had significantly decreased DRA- and FT- derived myocardial strain measurements (allp< 0.05). There was a significant correlation and high reproducibility between the DRA- and FT-derived strain parameters. Both CMR-derived LVGLS and LVGRS were significantly related to the presence of LGE, and multivariate logistic regression analyses showed that the LVGLS measurement obtained from both techniques was independently associated with the presence of LGE. The odds ratios (ORs) for DRA- and FT-LVGLS were 1.340 and 1.342, respectively.ConclusionsAsymptomatic HT patients with preserved LVEF exhibited reduced myocardial strain parameters. The CMR-derived LVGLS was independently related to the presence of LGE in HT patients.Key Points• Reduced myocardial strain parameters were found in asymptomatic heart transplanted (HT) patients with normal left ventricular ejection fraction (LVEF).• The deformation registration algorithm (DRA) and feature tracking (FT)–derived strains in asymptomatic HT patients had high reproducibility.• DRA- and FT-derived LVGLS had an independent relationship with late gadolinium enhancement (LGE) in asymptomatic HT patients.