A comparison of the pro-inflammatory, NF-κB-dependent cytokines:: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients
A comparison of the pro-inflammatory, NF-κB-dependent cytokines:: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients
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DOI：
10.1016/j.clim.2004.12.003
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发表时间：
2005-03-01
影响因子：
8.6
通讯作者：
Ondrey, F
中科院分区：
文献类型：
--
作者：
Rhodus, NL;Cheng, B;Ondrey, F
为了探索检测口腔扁平苔藓 (OLP) 患者口腔液中 NF-KB 依赖性细胞因子水平的临床应用可行性，13 名 OLP 受试者和 13 名年龄性别匹配的对照者被纳入该研究。通过标准技术收集每个受试者的全部未刺激唾液（WUS）、唾液和等渗盐水口腔冲洗液的混合物（唾液-NaCl）以及病变组织渗出液（TT）。通过 ELISA 测定三种口腔液中细胞因子 TNF-α、IL-1-α、IL-6 和 IL-8 的水平。在这三种类型的口腔液中，OLP 患者检测到的这些细胞因子水平显着高于正常对照。这些结果表明，某些口腔液中可能检测到 NF-KB 依赖性炎症细胞因子水平升高，这可能具有监测 OLP 患者疾病活动性和做出治疗决策的诊断和预后潜力。 (C) 2004 Elsevier Inc. 保留所有权利。
To explore the feasibility of detection of the level of NF-KB-dependent cytokines in oral fluids from patient with oral lichen planus (OLP) for clinical application, 13 OLP subjects were enrolled in the study as were 13 age-sex-matched controls. In each subject, the whole unstimulated saliva (WUS), mixture of saliva and isotonic saline oral rinse (Saliva-NaCl), and lesion tissue transudates (TT) were collected by standard techniques. The level of cytokines, TNF-alpha, IL-1-alpha, IL-6, and IL-8 in three types of oral fluids was determined by ELISA. In the three types of oral fluids, a significantly higher level of these cytokines was detected in OLP patients than in normal controls. These results indicate that NF-KB-dependent inflammatory cytokines may be detected at increased levels in certain oral fluids which may have diagnostic and prognostic potential for monitoring disease activity and making therapeutic decisions in patients with OLP. (C) 2004 Elsevier Inc. All rights reserved.