Expression of bone morphogenetic proteins in human prostatic adenocarcinoma and benign prostatic hyperplasia.
Expression of bone morphogenetic proteins in human prostatic adenocarcinoma and benign prostatic hyperplasia.
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DOI：
10.1038/bjc.1992.427
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发表时间：
1992-12
影响因子：
8.8
通讯作者：
Russell, R G
中科院分区：
文献类型：
--
作者：
Bentley, H;Hamdy, F C;Hart, K A;Seid, J M;Williams, J L;Johnstone, D;Russell, R G
前列腺肿瘤和骨骼之间有重要的相互作用。本研究旨在探讨前列腺组织是否可以表达骨诱导因子，特别是骨形态发生蛋白（bone Morphogenetic Proteins, BMPs）。聚合酶链反应（PCR）用于筛选BMPs 1 - 6在良性前列腺增生（BPH）、非转移性前列腺腺癌和转移性前列腺腺癌患者前列腺组织中的表达。良性和恶性前列腺组织以及前列腺肿瘤细胞系PC3和DU145均表达bmp。bmp也在眼黑色素瘤组织中表达，这种组织很少转移到骨。超过50%临床定义的转移性前列腺癌患者的前列腺组织中检测到BMP-6的表达，但在非转移性或良性前列腺样本或眼部黑色素瘤组织中未检测到BMP-6的表达。这些发现提示bmp可能在前列腺转移的骨诱导活性中起作用，并且bmp的表达模式可能在前列腺腺癌相关成骨细胞转移的发病机制中起重要作用。
There are important interactions between prostatic tumours and bone. This study was designed to examine whether prostatic tissue can express bone inductive factors, in particular, the Bone Morphogenetic Proteins (BMPs). The polymerase chain reaction (PCR) has been used to screen for the expression of BMPs one to six in the prostatic tissue of patients with benign prostatic hyperplasia (BPH), non-metastatic prostatic adenocarcinoma and metastatic prostatic adenocarcinoma. BMPs were expressed in both benign and malignant prostate tissue and in the prostate tumour cell lines, PC3 and DU145. BMPs were also expressed in ocular melanoma tissue, a tissue which rarely metastasizes to bone. BMP-6 expression was detected in the prostate tissue of over 50% of patients with clinically defined metastatic prostate adenocarcinoma, but was not detected in non-metastatic or benign prostate samples or in ocular melanoma tissue. These findings suggest that the BMPs may play a role in the osteoinductive activity of prostate metastases and that the pattern of expression of BMPs may be important in the pathogenesis of osteoblastic metastases associated with prostate adenocarcinoma.