A facile synthesis of versatile Cu2-xS nanoprobe for enhanced MRI and infrared thermal/photoacoustic multimodal imaging
A facile synthesis of versatile Cu2-xS nanoprobe for enhanced MRI and infrared thermal/photoacoustic multimodal imaging
复制标题
DOI：
10.1016/j.biomaterials.2015.04.020
复制
发表时间：
2015-07-01
期刊：
影响因子：
14
通讯作者：
Chen, Hangrong
中科院分区：
文献类型：
--
作者：
Mou, Juan;Liu, Chengbo;Chen, Hangrong
通过热分解和仿生磷脂修饰，以单一组分Cu 2-xS为模板，快速合成了一种新型的智能纳米探针，使其具有均匀、小的纳米颗粒尺寸（约15 nm）、良好的磷酸盐缓冲液分散性、高稳定性和良好的生物相容性。合成的Cu 2-x纳米探针（Cu 2-xS NPs）能够为T1加权磁共振成像（MRI）提供对比度增强，首次通过体外和体内成像研究证明。此外，由于其强的近红外（NIR）光学吸收，它们也可以作为增强红外热/光声成像的候选造影剂，以满足MRI的不足。因此，可以获得补充和可能更全面的信息，用于癌症的早期检测和准确诊断。此外，在3个月的相对较长时间内观察到对血液和组织的全身副作用可忽略不计。Cu 2-xS纳米颗粒独特的多模态成像能力和出色的血液/组织相容性，为未来检测和诊断癌症或其他疾病开辟了新的分子成像可能性。(C)2015爱思唯尔有限公司版权所有。
A novel type of intelligent nanoprobe by using single component of Cu2-xS for multimodal imaging has been facilely and rapidly synthesized in scale via thermal decomposition followed by biomimetic phospholipid modification, which endows them with uniform and small nanoparticle size (ca.15 nm), well phosphate buffer saline (PBS) dispersity, high stability, and excellent biocompatibility. The assynthesized Cu2-x nanoprobes (Cu2-xS NPs) are capable of providing contrast enhancement for T1-weighted magnetic resonance imaging (MRI), as demonstrated by the both in vitro and in vivo imaging investigations for the first time. In addition, due to their strong near infrared (NIR) optical absorption, they can also serve as a candidate contrast agent for enhanced infrared thermal/photoacoustic imaging, to meet the shortfalls of MRI. Hence, complementary and potentially more comprehensive information can be acquired for the early detection and accurate diagnosis of cancer. Furthermore, negligible systematic side effects to the blood and tissue were observed in a relatively long period of 3 months. The distinctive multimodal imaging capability with excellent hemo/histocompatibility of the Cu2-xS NPs could open up a new molecular imaging possibility for detecting and diagnosing cancer or other diseases in the future.(C) 2015 Elsevier Ltd. All rights reserved.