Clinical aspects of intestinal neuronal dysplasia
Clinical aspects of intestinal neuronal dysplasia
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DOI：
10.1053/jpsu.2002.36720
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发表时间：
2002-12-01
影响因子：
2.4
通讯作者：
Fadda, B
中科院分区：
文献类型：
--
作者：
Montedonico, S;Acevedo, S;Fadda, B
目的：本研究的目的是确定肠道神经元发育不良 (IND) 是否存在特定的临床症状，以及它是否与组织病理学结果的严重程度相关。方法：将一组 44 例严重 IND 患者和一组通过组织化学直肠活检诊断的 16 例轻度 IND 患者与一组 37 例直肠活检结果正常的功能性便秘 (FC) 患者进行比较。结果：严重 IND 患者出现症状的年龄较早。患有轻度 IND 和 FC 的患者（分别为 5.2 +/- 112 个月 vs 17.5 +/- 23 个月和 22.5 +/- 21.8 个月；P
Purpose: The aim of this study was to determine the presence of specific clinical symptoms in intestinal neuronal dysplasia (IND) and whether it correlates to the severity of histopathologic findings.Methods: A group of 44 severe IND and a group of 16 mild IND patients diagnosed by means of a histochemical rectal biopsy were compared with a group of 37 patients with functional constipation (FC) with normal rectal biopsy results.Results: Patients with severe IND began their symptoms at an earlier age than those with mild IND and FC (5.2 +/- 112 months v 17.5 +/- 23 months and 22.5 +/- 21.8 months, respectively; P