THE EFFECT OF ULTRASOUND ON MICRO-VASCULAR HEMODYNAMICS IN SKELETAL-MUSCLE - EFFECT ON ARTERIOLES
THE EFFECT OF ULTRASOUND ON MICRO-VASCULAR HEMODYNAMICS IN SKELETAL-MUSCLE - EFFECT ON ARTERIOLES
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DOI：
10.1016/0301-5629(82)90068-0
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发表时间：
1982-01-01
影响因子：
2.9
通讯作者：
BURKE, KM
中科院分区：
文献类型：
--
作者：
HOGAN, RD;FRANKLIN, TD;BURKE, KM
描述了骨骼肌模型（大鼠提睾肌），用于评估超声对微观血管系统的生物效应。以1.25、2.5、5.0和10.0 W cm-2（时间平均值）向组织施用1 MHz脉冲超声（标记-间隔100 μ s：100 μ s），同时连续测量3种不同尺寸的小动脉（100、50、30 μ m内径）中的管腔直径、体积流量和血管运动速率（固有周期性收缩和舒张）。在低于5 W cm-2的强度下，未观察到这些参数的变化。在5 W cm-2以上，观察到的最小动脉的直径减少25%，体积流量减少44%，供给组织的最大小动脉的流量减少29%。在相同的强度范围内，最小的小动脉的血管舒缩率增加了20倍。这些效应或它们的大小都不能归因于相同温度范围（34 - 36.5 ℃）内的简单组织加热。C）如通过超声暴露获得的。
A skeletal muscle model (rat cremaster muscle) was described for the evaluation of ultrasonic bioeffects on the microscopic vasculature. One MHz pulsed ultrasound (mark-space 100 .mu.s:100 .mu.s) was administered to the tissue at 1.25, 2.5, 5.0 and 10.0 W cm-2 (temporal average) while continuously measuring lumen diameter, volume flow and rate of vasomotion (intrinsic cyclic constriction and relaxation) in 3 different sizes of arterioles (100, 50, 30 .mu.m inner diameter). No change in these parameters was noted at intensities below 5 W cm-2. Above 5 W cm-2 there was a 25% decrease in diameter and a 44% decrease in volume flow in the smallest arterioles observed and a 29% decrease in flow in the largest arteriole feeding the tissue. The rate of vasomotion in the smallest arterioles increased 20 times in the same intensity range. None of these effects or their magnitude could be attributed to simple tissue heating in the same temperature range (34-36.5.degree. C) as obtained with ultrasound exposures.