Origin of CD11b+ macrophage-like cells in the CNS of PLP-overexpressing mice: Low influx of haematogenous macrophages and unchanged blood-brain-barrier in the optic nerve
Origin of CD11b+ macrophage-like cells in the CNS of PLP-overexpressing mice: Low influx of haematogenous macrophages and unchanged blood-brain-barrier in the optic nerve
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DOI：
10.1016/j.mcn.2008.04.009
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发表时间：
2008-08-01
影响因子：
3.5
通讯作者：
Martini, Rudolf
中科院分区：
文献类型：
--
作者：
Ip, Chi Wang;Kohl, Bianca;Martini, Rudolf
我们最近报道了少突胶质细胞中蛋白脂蛋白的过度表达导致CNS中CD8+ t淋巴细胞和CD11b+细胞的病理相关增加。我们现在把重点放在视神经中CD11b+细胞的起源上，这是一个用于分析突变体的成熟结构，使用骨髓嵌合小鼠。尽管突变体视神经有髓鞘部分的CD11b+细胞与年龄相关，但浸润细胞的百分比并未增加，但可以检测到增殖增强。在无髓鞘视神经头，浸润CD11b+细胞和白蛋白外渗的命运在两种基因型中都很高。然而，在吻侧髓鞘部分白蛋白外渗也很高，CD11b+细胞内流较低。我们的研究表明，在CNS髓磷脂突变体中，在血脑屏障不变的情况下，CD11b+细胞的内在起源。(C) 2008爱思唯尔公司版权所有。
We have recently reported that overexpression of proteolipid protein in oligodendrocytes leads to a pathologically relevant increase of both CD8+ T-lymphocytes and CD11b+ cells in the CNS. We now focussed on the origin of the CD11b+ cells in the optic nerve, a well established structure for the analysis of the mutant, using bone marrow chimeric mice. Although there is an age-related increase in CD11b+ cells in the myelinated part of the optic nerve of the mutants, the percentage of infiltrating cells was not increased, but enhanced proliferation was detectable. In the non-myelinated optic nerve head, the Fate of infiltrating CD11b+ cells and albumin extravasation was high in both genotypes. However, albumin extravasation was also high in the rostral myelinated part, where CD11b+ cell influx was low. Our study demonstrates an intrinsic origin of CD11b+ cells in the presence of an unchanged blood-brain-barrier in a CNS myelin mutant. (C) 2008 Elsevier Inc. All rights reserved.