Shape Anisotropy Enhances Nanoparticle Dynamics in Nearly Homogeneous Hydrogels
Shape Anisotropy Enhances Nanoparticle Dynamics in Nearly Homogeneous Hydrogels
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DOI：
10.1021/acs.macromol.2c01577
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发表时间：
2022-09
期刊：
影响因子：
5.5
通讯作者：
K. A. Rose;Natalie Gogotsi;Jonathan H. Galarraga;J. Burdick;C. Murray;Daeyeon Lee;R. Composto
中科院分区：
文献类型：
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作者：
K. A. Rose;Natalie Gogotsi;Jonathan H. Galarraga;J. Burdick;C. Murray;Daeyeon Lee;R. Composto
采用单粒子跟踪方法研究了纳米粒子形状各向异性对动力学的影响。考察了聚乙二醇化的量子点(QD)和直径相近的量子棒(QR)探针在四聚乙二醇(TETRA-PEGO)水凝胶凝胶过程中的均方位移。在凝胶时间(TGel)之前的早期，量子点比它们的QR对应物表现出更大的迁移率。然而，随着凝胶化的进行，QR表现出比量子点更强的动力学，这表明在越来越受限的网络中增强了棒的动力学。讨论了可能的机制，包括旋转动力学的影响和杆在受限系统中平行扩散的增加。这项研究为开发不同形状各向异性的纳米颗粒探针提供了见解，尤其对于它们在药物输送和其他生物医学应用中的使用具有特别重要的意义。
Single particle tracking is used to investigate the effect of nanoparticle shape anisotropy on dynamics. The mean squared displacements of poly(ethylene glycol) (PEG)-functionalized quantum dot (QD) and quantum rod (QR) probes of similar diameters are examined during the gelation of a tetra-poly(ethylene glycol) (tetra-PEG) hydrogel. At early times prior to the gel time (tgel), QDs exhibit greater mobility than their QR counterparts. However, as gelation proceeds, QRs exhibit increased dynamics compared to QDs, suggesting enhanced rod dynamics in increasingly confined networks. Potential mechanisms are discussed, including the influence of rotational dynamics and the increased parallel diffusion of rods in confined systems. This study provides insights into developing nanoparticle probes of different shape anisotropy, with particular importance for their use in drug delivery and other biomedical applications.