Spatial memory and hippocampal volume in humans with unilateral vestibular deafferentation
Spatial memory and hippocampal volume in humans with unilateral vestibular deafferentation
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DOI：
10.1002/hipo.20283
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发表时间：
2007-01-01
期刊：
影响因子：
3.5
通讯作者：
Brandt, Thomas
中科院分区：
文献类型：
--
作者：
Huefner, Katharina;Hamilton, Derek A.;Brandt, Thomas
获得性慢性双侧前庭缺失的患者最近被发现在进行虚拟Morris水任务测试时，在空间记忆和导航方面有明显的损害。这些缺陷与选择性和双侧海马体萎缩有关，这表明空间记忆和导航也依赖前庭输入。本研究对16例听神经瘤所致单侧前庭神经传入障碍患者进行了术后5~13年的检查。在患者和年龄和性别匹配的健康对照组中，通过手动跟踪海马体结构和基于体素的形态测量进行了海马体体积测量。用虚拟Morris水任务评估空间记忆和导航能力。左前庭功能衰竭的患者在空间记忆和导航方面没有明显的缺陷，而右前庭功能丧失的患者在各自的测试中表现出更差的倾向。减损w，仅对一项计算测量(航向误差)显著。右前庭缺失的细微缺陷与最近描述的右迷路和右半球前庭皮质的优势是一致的。容量测量没有显示任何患者组的海马体萎缩。(C)2007年Wiley-Liss，Inc.
Patients with acquired chronic bilateral vestibular loss were recently found to have a significant impairment in spatial memory and navigation when tested with a virtual Morris water task. These deficits were associated with selective and bilateral atrophy of the hippocampus, which suggests that spatial memory and navigation also rely on vestibular input. In the present study 16 patients with unilateral vestibular deafferentation due to acoustic neurinoma were examined 5- to 13-yrs post-surgery. Volumetry of the hippocampus was performed in patients and age- and sex-matched healthy controls by manually tracing the structure and by an evaluator-independent voxel-based morphometry. Spatial memory and navigation were assessed with a virtual Morris water task. No significant deficits in spatial memory and navigation could be demonstrated in the patients with left vestibular failure, whereas patients with right vestibular loss showed a tendency to perform worse on the respective tests. impairment w, as significant only for one computed measure (heading error). The subtle deficiencies with right vestibular loss are compatible with the recently described dominance of the right labyrinth and the vestibular cortex in the right hemisphere. Volumetry did not reveal any atrophy of the hippocampus in either patient group. (C) 2007 Wiley-Liss, Inc.