Stress granules in colorectal cancer: Current knowledge and potential therapeutic applications.
Stress granules in colorectal cancer: Current knowledge and potential therapeutic applications.
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结直肠癌中的应激颗粒：当前知识和潜在的治疗应用。
DOI：
10.3748/wjg.v26.i35.5223
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发表时间：
2020-09-21
影响因子：
4.3
通讯作者：
Sobolewski C
中科院分区：
文献类型：
--
作者：
Legrand N;Dixon DA;Sobolewski C
应激颗粒（SG）代表重要的非膜细胞质区室，参与细胞对各种应激条件（例如缺氧、营养缺乏、氧化应激）的适应。这些颗粒含有多种支架蛋白和 RNA 结合蛋白，它们与 mRNA 结合并保持它们的翻译沉默，同时保护它们免受有害条件的影响。尽管 SGs 在癌症发展中的作用仍然知之甚少，并且因癌症类型而异，但越来越多的证据表明，几种关键 SGs 成分的表达和/或活性在结直肠肿瘤中以及在肿瘤前期（例如炎症性肠病）中均失调，因此表明其在结直肠癌 (CRC) 的发病中具有潜在作用。因此，人们相信SGs的形成对结直肠肿瘤发生的各个步骤以及化疗耐药性都有重要贡献。由于结直肠癌是第三大常见癌症，也是全球癌症死亡的主要原因之一，因此需要开发新的治疗靶点来抵消化疗耐药性的发展和转移的形成。因此，废除 SGs 组装可能代表了一种有吸引力的治疗策略，可以使结肠癌细胞重新对抗癌化疗敏感。在这篇综述中，我们总结了结直肠癌中 SG 的当前知识以及可用于针对它们的潜在治疗策略。
Stress granules (SGs) represent important non-membrane cytoplasmic compartments, involved in cellular adaptation to various stressful conditions (e.g., hypoxia, nutrient deprivation, oxidative stress). These granules contain several scaffold proteins and RNA-binding proteins, which bind to mRNAs and keep them translationally silent while protecting them from harmful conditions. Although the role of SGs in cancer development is still poorly known and vary between cancer types, increasing evidence indicate that the expression and/or the activity of several key SGs components are deregulated in colorectal tumors but also in pre-neoplastic conditions (e.g., inflammatory bowel disease), thus suggesting a potential role in the onset of colorectal cancer (CRC). It is therefore believed that SGs formation importantly contributes to various steps of colorectal tumorigenesis but also in chemoresistance. As CRC is the third most frequent cancer and one of the leading causes of cancer mortality worldwide, development of new therapeutic targets is needed to offset the development of chemoresistance and formation of metastasis. Abolishing SGs assembly may therefore represent an appealing therapeutic strategy to re-sensitize colon cancer cells to anti-cancer chemotherapies. In this review, we summarize the current knowledge on SGs in colorectal cancer and the potential therapeutic strategies that could be employed to target them.
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影响因子：
4.8
作者：
Byrd, Alicia K.;Zybailov, Boris L.;Raney, Kevin D.
通讯作者：
Raney, Kevin D.
Pdcd4 参与氧化低密度脂蛋白或高脂肪饮食引起的应激颗粒的形成
影响因子：
3.7
作者：
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通讯作者：
Wang Q
影响因子：
14.9
作者：
Bley N;Lederer M;Pfalz B;Reinke C;Fuchs T;Glaß M;Möller B;Hüttelmaier S
通讯作者：
Hüttelmaier S
影响因子：
64.5
作者：
Buchan, J. Ross;Kolaitis, Regina-Maria;Parker, Roy
通讯作者：
Parker, Roy
影响因子：
9.2
作者：
Cirillo, Luca;Cieren, Adeline;Gotta, Monica
通讯作者：
Gotta, Monica