Association studies of MAO-A, COMT, and 5-HTT genes polymorphisms in patients with anxiety disorders of the phobic spectrum
Association studies of MAO-A, COMT, and 5-HTT genes polymorphisms in patients with anxiety disorders of the phobic spectrum
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DOI：
10.1016/j.psychres.2004.05.012
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发表时间：
2004-08-30
影响因子：
11.3
通讯作者：
Kucharska-Mazur, J
中科院分区：
文献类型：
--
作者：
Samochowiec, J;Hajduk, A;Kucharska-Mazur, J
最近的研究提供证据表明，焦虑症可能与5-羟色胺神经传递功能障碍或代谢儿茶酚胺的酶活性受损有关。对101例焦虑谱系恐怖症患者和202例性别、年龄和种族相匹配的对照者进行了MAO-A uVNTR启动子基因、COMT基因（Vall 58 Met）外显子4和5-HTT启动子基因（44 bp插入/缺失）的功能多态性研究。5-HTT和COMT基因多态性的等位基因和基因型频率在对照组和患者之间无显著差异。MAO-A基因多态性的>3个重复等位基因的频率在患有焦虑症，特别是惊恐发作和广泛性焦虑症的女性患者中显著较高。与社交恐怖症女性患者相比，广场恐怖症和特定恐怖症女性患者中也存在>3个重复等位基因更频繁出现的趋势，而社交恐怖症女性患者与对照组没有差异。结果支持MAO-A基因在焦虑症中的可能作用。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
Recent studies provide evidence that anxiety disorders may be linked to malfunction of serotonin neurotransmission or impaired activity of enzymes metabolising the catecholamines. Functional polymorphisms in the MAO-A uVNTR promoter Gene, the COMT gene (Vall58Met) exon 4, and the 5-HTT promoter gene (44 bp ins/del) were investigated in 101 patients with phobic disorders of the anxiety spectrum and 202 controls matched to the patients for sex, age and ethnicity. There were no significant differences between controls and patients in the allele and genotype frequencies of the 5-HTT and COMT gene polymorphisms. The frequency of >3 repeat alleles of the MAO-A gene polymorphism was significantly higher in female patients suffering from anxiety disorders, specifically panic attacks and generalized anxiety disorder. There was also a trend for the more frequent presence of >3 repeat alleles in female patients with agoraphobia and specific phobia, in contrast to female patients with social phobia, who did not differ from controls. The results support a possible role of the MAO-A gene in anxiety disorders. (C) 2004 Elsevier Ireland Ltd. All rights reserved.