Diagnostic and Therapeutic Roles of Extracellular Vesicles in Aging-Related Diseases.
Diagnostic and Therapeutic Roles of Extracellular Vesicles in Aging-Related Diseases.
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DOI：
10.1155/2022/6742792
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发表时间：
2022
影响因子：
--
通讯作者：
Qian, Hui
中科院分区：
文献类型：
--
作者：
Sun, Zixuan;Hou, Xiaomei;Zhang, Jiaxin;Li, Jiali;Wu, Peipei;Yan, Lirong;Qian, Hui
衰老表现为整体生理功能的衰退，而细胞衰老则是导致衰老的强大催化剂。鉴于衰老会伴随各种与衰老相关疾病的出现，研发新型抗衰老药物仍具有重要价值。细胞外囊泡（EVs）作为细胞间通讯的工具，是衰老相关分泌表型（SASP）的重要组成部分，在细胞衰老过程中发挥着病理作用。此外，细胞外囊泡在功能上与其来源的原始细胞相似。因此，源自病理组织或体液的细胞外囊泡可能与疾病进展密切相关，并有可能成为潜在的生物标志物，而源自健康细胞的细胞外囊泡则可能具有治疗作用。再者，细胞外囊泡是理想的药物载体。目前，大量研究表明，经过工程改造的细胞外囊泡能够提高药物靶向能力和利用效率。在此，我们总结了细胞外囊泡和细胞衰老的特征，并重点阐述细胞外囊泡在多种与衰老相关疾病中的诊断和治疗潜力，这些疾病包括阿尔茨海默病、骨质疏松症、心血管疾病、糖尿病及其并发症以及皮肤衰老。
Aging shows a decline in overall physical function, and cellular senescence is the powerful catalyst leading to aging. Considering that aging will be accompanied with the emergence of various aging-related diseases, research on new antiaging drugs is still valuable. Extracellular vesicles (EVs), as tools for intercellular communication, are important components of the senescence-associated secretory phenotype (SASP), and they can play pathological roles in the process of cellular senescence. In addition, EVs are similar to their original cells in functions. Therefore, EVs derived from pathological tissues or body fluids may be closely related to the progression of diseases and become potential biomarkers, while those from healthy cells may have therapeutic effects. Moreover, EVs are satisfactory drug carriers. At present, numerous studies have supported the idea that engineered EVs could improve drug targeting ability and utilization efficiency. Here, we summarize the characteristics of EVs and cellular senescence and focus on the diagnostic and therapeutic potential of EVs in various aging-related diseases, including Alzheimer disease, osteoporosis, cardiovascular disease, diabetes mellitus and its complications, and skin aging.
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影响因子：
16
作者：
Feng, Rui;Ullah, Mujib;Sun, Zhongjie
通讯作者：
Sun, Zhongjie
影响因子：
5.6
作者：
Chandra A;Rajawat J
通讯作者：
Rajawat J
影响因子：
16
作者：
Barreiro K;Dwivedi OP;Leparc G;Rolser M;Delic D;Forsblom C;Groop PH;Groop L;Huber TB;Puhka M;Holthofer H
通讯作者：
Holthofer H
阿尔茨海默氏病的细胞外囊泡生物标志物与中期晚期临界认知下降有关。
DOI：
10.1002/alz.12130
发表时间：
2020-09
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Eren E;Hunt JFV;Shardell M;Chawla S;Tran J;Gu J;Vogt NM;Johnson SC;Bendlin BB;Kapogiannis D
通讯作者：
Kapogiannis D
DOI：
10.1161/hypertensionaha.118.11239
发表时间：
2018-08
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Cambier L;Giani JF;Liu W;Ijichi T;Echavez AK;Valle J;Marbán E
通讯作者：
Marbán E