Differential effects of anti-Nogo-A antibody treatment and treadmill training in rats with incomplete spinal cord injury
Differential effects of anti-Nogo-A antibody treatment and treadmill training in rats with incomplete spinal cord injury
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DOI：
10.1093/brain/awp085
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发表时间：
2009-06-01
期刊：
影响因子：
14.5
通讯作者：
Schwab, Martin E.
中科院分区：
文献类型：
--
作者：
Maier, Irin C.;Ichiyama, Ronaldo M.;Schwab, Martin E.
跑步机上的运动训练可以改善脊髓损伤动物和患者的行走恢复。同样，用针对髓磷脂相关神经突生长抑制蛋白 Nogo-A 的抗体治疗的病变大鼠表现出再生、神经元重组和行为改善的增强。详细的运动学分析表明，经过抗Nogo-A抗体治疗的大鼠与经过跑步机训练的脊髓损伤大鼠所形成的后肢运动模式显着不同。同步联合治疗组未表现出协同作用。这种协同效应的缺乏不能用疼痛感知的增加、降钙素基因相关肽（CGRP）阳性纤维的萌芽或抗Nogo-A抗体诱导的下行纤维束的再生和萌芽干扰运动训练来解释。在设计组合疗法时，必须考虑在特定任务训练期间以及再生或可塑性增强疗法中导致行为恢复的不同机制，以便充分表达其潜在的积极相互作用。
Locomotor training on treadmills can improve recovery of stepping in spinal cord injured animals and patients. Likewise, lesioned rats treated with antibodies against the myelin associated neurite growth inhibitory protein, Nogo-A, showed increased regeneration, neuronal reorganization and behavioural improvements. A detailed kinematic analysis showed that the hindlimb kinematic patterns that developed in anti-Nogo-A antibody treated versus treadmill trained spinal cord injured rats were significantly different. The synchronous combined treatment group did not show synergistic effects. This lack of synergistic effects could not be explained by an increase in pain perception, sprouting of calcitonin gene-related peptide (CGRP) positive fibres or by interference of locomotor training with anti-Nogo-A antibody induced regeneration and sprouting of descending fibre tracts. The differential mechanisms leading to behavioural recovery during task-specific training and in regeneration or plasticity enhancing therapies have to be taken into account in designing combinatorial therapies so that their potential positive interactive effects can be fully expressed.