The relationship between hue discrimination and contrast sensitivity deficits in patients with diabetes mellitus.
The relationship between hue discrimination and contrast sensitivity deficits in patients with diabetes mellitus.
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DOI：
10.1016/s0161-6420(88)33125-8
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发表时间：
1988-05
期刊：
影响因子：
13.7
通讯作者：
Gary L. Trick;Ronald M. Burde;Mae O. Cordon;Julio V. Santiago;C. Kilo
中科院分区：
文献类型：
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作者：
Gary L. Trick;Ronald M. Burde;Mae O. Cordon;Julio V. Santiago;C. Kilo
为了更全面地阐明糖尿病患者早期视功能障碍的病理生理学基础，对57例糖尿病视网膜病变患者和35例年龄匹配的正常人进行了色觉(色调辨别)和空间分辨率(对比敏感度)测试。37.8%的糖尿病无视网膜病变者和60.0%的糖尿病有背景性视网膜病变者有视功能障碍。尽管两组糖尿病患者均存在明显的色调辨别和对比敏感度缺陷，但对比敏感度的异常比色调辨别更常见。而在无视网膜病变的糖尿病患者中，仅有5.4%的患者和有背景视网膜病变的糖尿病患者中有10.0%的患者同时表现出异常的色调辨别和对比敏感度。与以前的报告相反，蓝-黄(B-Y)和红-绿(R-G)色调辨别缺陷的出现频率大致相同。在糖尿病组中，对比敏感度在所有测试的空间频率上都降低了，但对于个别糖尿病患者来说，显著的缺陷只在中端空间频率上明显。在糖尿病患者中，色调辨别缺陷与患者的血红蛋白A1水平相关，而与对比敏感度异常无关。6.0CPD对比敏感度与糖尿病病程呈负相关。
In an attempt to elucidate more fully the pathophysiologic basis of early visual dysfunction in patients with diabetes mellitus, color vision (hue discrimination) and spatial resolution (contrast sensitivity) were tested in diabetic patients with little or no retinopathy (n = 57) and age-matched visual normals (n = 35). Some evidence of visual dysfunction was observed in 37.8% of the diabetics with no retinopathy and 60.0% of the diabetics with background retinopathy. Although significant hue discrimination and contrast sensitivity deficits were observed in both groups of diabetic patients, contrast sensitivity was abnormal more frequently than hue discrimination. However, only 5.4% of the diabetics with no retinopathy and 10.0% of the diabetics with background retinopathy exhibited both abnormal hue discrimination and abnormal contrast sensitivity. Contrary to previous reports, blue-yellow (B-Y) and red-green (R-G) hue discrimination deficits were observed with approximately equal frequency. In the diabetic group, contrast sensitivity was reduced at all spatial frequencies tested, but for individual diabetic patients, significant deficits were only evident for the mid-range spatial frequencies. Among diabetic patients, the hue discrimination deficits, but not the contrast sensitivity abnormalities, were correlated with the patients' hemoglobin A1 level. A negative correlation between contrast sensitivity at 6.0 cpd and the duration of diabetes also was observed.