The significant change for the timed 25-foot walk in the multiple sclerosis functional composite
The significant change for the timed 25-foot walk in the multiple sclerosis functional composite
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DOI：
10.1191/135245800678827860
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发表时间：
2000-08-01
期刊：
影响因子：
--
通讯作者：
Norton, J
中科院分区：
文献类型：
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作者：
Kaufman, M;Moyer, D;Norton, J
计时25英尺步行正在接受评估，作为随访多发性硬化症患者的临床工具。有几种方法可以定义该测量值的临床显着变化。本研究的目的是定义计时25英尺步行的预期值范围，并前瞻性地关联步行变化-与主观行走困难相关的MS急性发作期间发生的时间，强调了本研究的五个结果。(1)受MS影响最小的患者经常在3到5秒内步行25英尺。(2)步行时间变异性，定义为最长步行时间与最短步行时间之比，减去1，乘以三次连续试验的100%，通常为20%或更小;（3）如果比较三次试验中获得的两个最快步行时间，步行时间变异性几乎总是10%或更小;（4）对于临床稳定的个体，间隔12个月或更短的单次试验的步行时间的变化通常小于20%;（5）主诉行走困难但检查无异常者，行走时间延长。这些结果表明，在定时25英尺步行中增加超过20%可能表明步态发生了显著变化。
The Timed 25-Foot Walk is under evaluation as a clinical tool to follow Patients with MS. Several approaches have been token to define a clinically significant change in this measurement This study was undertaken to define the range of values expected for the Timed 25-Foot Walk and to correlate prospectively the change in walk-time that occurs during on exacerbation of MS associated with subjective difficulty walking Five results from this study ore emphasized. (1) Patients who were minimally affected by MS frequently walked 25 feet between three and five seconds. (2) the walk-time variability, defined of the ratio of the longest to the shortest walk-time, minus 1, times 100% for three consecutive trials was generally 20% or less; (3) if the two fastest walk-times obtained in three trials were compared, the walk-time variability was almost always 10% or less; (4) for clinically stable individuals, the walk-times of single trials separated by 12 months or less generally varied less than 20%; and (5) patients who complained of difficulty walking but who did not hove changes otherwise detectable by examination, generally had a prolongation of walk-time. These results suggest that on increase of more than 20% in the Timed 25-Foot Walk may indicate a significant change in gait.