Mortality of rheumatoid arthritis in Japan: a longitudinal cohort study
Mortality of rheumatoid arthritis in Japan: a longitudinal cohort study
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DOI：
10.1136/ard.2004.033761
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发表时间：
2005-10-01
影响因子：
27.4
通讯作者：
Fujiwara, S
中科院分区：
文献类型：
--
作者：
Hakoda, M;Oiwa, H;Fujiwara, S
目的：在考虑生活方式和身体因素（包括合并症）的情况下，确定日本类风湿性关节炎患者的死亡风险。方法：在1958年至1966年期间对16119名日本原子弹幸存者进行筛查时，确定了91名类风湿关节炎患者。这些个体和其他人群的死亡率被跟踪到1999年。类风湿患者的死亡风险采用Cox比例风险模型估计。除年龄和性别外，生活方式和身体因素，如吸烟状况、饮酒、血压和合并症，也被纳入总死亡率分析和每种死因死亡率分析的调整因素。结果：在17.8年和28.0年的平均随访期间，类风湿患者中有83人（91.2%）死亡，非类风湿对照组中有8527人（52.9%）死亡。类风湿患者经年龄和性别调整后的死亡率风险比为1.60（95%可信区间为1.29 ~ 1.99）
Objective: To determine the mortality risk of Japanese patients with rheumatoid arthritis, taking into account lifestyle and physical factors, including comorbidity.Methods: 91 individuals with rheumatoid arthritis were identified during screening a cohort of 16 119 Japanese atomic bomb survivors in the period 1958 to 1966. These individuals and the remainder of the cohort were followed for mortality until 1999. Mortality risk of the rheumatoid patients was estimated by the Cox proportional hazards model. In addition to age and sex, lifestyle and physical factors such as smoking status, alcohol consumption, blood pressure, and comorbidity were included as adjustment factors for the analysis of total mortality and for analysis of mortality from each cause of death.Results: 83 of the rheumatoid patients (91.2%) and 8527 of the non-rheumatoid controls (52.9%) died during mean follow up periods of 17.8 and 28.0 years, respectively. The age and sex adjusted hazard ratio for mortality in the rheumatoid patients was 1.60 (95% confidence interval, 1.29 to 1.99), p