SUPEROXIDE-DISMUTASE AND GLUTATHIONE-PEROXIDASE ACTIVITIES ARE INCREASED BY ENALAPRIL AND CAPTOPRIL IN MOUSE-LIVER
SUPEROXIDE-DISMUTASE AND GLUTATHIONE-PEROXIDASE ACTIVITIES ARE INCREASED BY ENALAPRIL AND CAPTOPRIL IN MOUSE-LIVER
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DOI：
10.1016/0014-5793(95)00137-x
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发表时间：
1995-03-13
期刊：
影响因子：
3.5
通讯作者：
FRAGA, CG
中科院分区：
文献类型：
--
作者：
DECAVANAGH, EMV;INSERRA, F;FRAGA, CG
本文研究了血管紧张素转换酶(ACE)抑制剂对小鼠铜锌超氧化物歧化酶(CuZn-SOD)、锰超氧化物歧化酶(Mn-SOD)、过氧化氢酶(CAT)和硒谷胱甘肽过氧化物酶(Se-GPx)活性的影响。给4月龄雌性CF1小鼠灌胃含依那普利(20 mg/L)或卡托普利(50 mg/L)的水，4~11周后，依那普利使CuZn-SOD、Mn-SOD和Se-GPx活性由19+/-4增加到46+/7，Se-GPx活性增加。2.1+/-0.2~3.8+/-0.2单位/毫克蛋白质和27+/-3~54+/-3毫单位/毫克蛋白质。治疗11周后，卡托普利使CuZn-SOD、MnSOD和Se-GPx的活性分别提高到35+/-4、2.9+/-0.2单位/mg蛋白质和38+/-2毫单位/mg蛋白质(P<；0.05)。过氧化氢酶活性不受处理的影响。这些结果表明，ACE抑制剂可能通过增加酶促抗氧化剂的防御来保护细胞成分免受氧化损伤。
We have characterized the effect of angiotensin converting enzyme (ACE) inhibitors on the activity of CuZn-superoxide dismutase (CuZn-SOD), Mn-superoxide dismutase (Mn-SOD), catalase, and selenium-dependent glutathione peroxidase (Se-GPx), CF1 mice (4-month-old females) were administered water containing enalapril (20 mg/l) or captopril (50 mg/l), during 4 to 11 weeks, After 11 weeks, enalapril treatment caused an increase in the activity of CuZn-SOD, Mn-SOD and Se-GPx, from 19 +/- 4 to 46 +/- 7, 2.1 +/- 0.2 to 3.8 +/- 0.2 units/mg protein and 27 +/- 3 to 54 +/- 3 milliunits/mg protein, respectively. After 11 weeks, captopril treatment increased the activities (P < 0.05) of CuZn-SOD, MnSOD and Se-GPx to 35 +/- 4, 2.9 +/- 0.2 units/mg protein, and 38 +/- 2 milliunits/mg protein, respectively. Catalase activity was not affected by the treatments. These results suggest that ACE inhibitors may protect cell components from oxidative damage by increasing the enzymatic antioxidant defenses.