Scope of the suzuki -: Miyaura aminoethylation reaction using organotrifluoroborates
Scope of the suzuki -: Miyaura aminoethylation reaction using organotrifluoroborates
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DOI：
10.1021/jo7015955
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发表时间：
2007-10-26
影响因子：
3.6
通讯作者：
Jean-Gerard, Ludivine
中科院分区：
文献类型：
--
作者：
Molander, Gary A.;Jean-Gerard, Ludivine
通过使用Snieckus硼氢化试剂使相应的烯氨基甲酸酯硼氢化，以良好的产率制备β-氨乙基三氟硼酸钾。在Suzuki-Miyaura偶联反应中，使用这些有机三氟硼酸酯与芳基溴、碘和三氟甲磺酸酯进行偶联，以良好的产率成功地制备了各种各样的含有潜在游离伯胺的苯乙胺。
Potassium beta-aminoethyltrifluoroborates were prepared in good yields via hydroboration of the corre- sponding enecarbamates using the Snieckus hydroborating reagent. A wide variety of phenethylamines containing a potentially free primary amine after appropriate deprotection have been successfully prepared in good yield using these organotrifluoroborates as partners in Suzuki-Miyaura coupling with aryl bromides, iodides, and triflates.