Dynamic regulation of host restriction factor expression over the course of HIV-1 infection in vivo.
Dynamic regulation of host restriction factor expression over the course of HIV-1 infection in vivo.
复制标题
HIV-1体内感染过程中宿主限制因子表达的动态调节。
DOI：
10.1128/jvi.01771-14
复制
发表时间：
2014
影响因子：
5.4
通讯作者：
Nixon,DouglasF
中科院分区：
文献类型：
--
作者：
Raposo,RuiAndréSaraiva;Abdel-Mohsen,Mohamed;Deng,Xutao;Hecht,FrederickM;Pilcher,ChristopherD;Pillai,SatishK;Nixon,DouglasF
In this study, we investigated the expression levels of host restriction factors in six untreated HIV-1-positive patients over the course of infection. We found that the host restriction factor gene expression profile consistently increased over time and was significantly associated with CD4+T cell activation and viral load. Our data are among the first to demonstrate the dynamic nature of host restriction factorsin vivoover time.
