Copolymers of 1,5-dioxepan-2-one and L- or D,L-dilactide: Hydrolytic degradation behavior
Copolymers of 1,5-dioxepan-2-one and L- or D,L-dilactide: Hydrolytic degradation behavior
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1,5-二氧杂环庚烷-2-酮和 L-或 D,L-二丙交酯的共聚物：水解降解行为
DOI：
10.1002/app.1994.070520917
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
A. Albertsson
中科院分区：
文献类型：
--
作者：
A. Löfgren;A. Albertsson
本文研究了1，5-二氧杂环庚烷-2-酮（DXO）与L-或D，L-二丙交酯的两个系列共聚物的降解。采用尺寸排阻色谱法（SEC）、核磁共振（NMR）光谱法、傅里叶变换红外（FTIR）光谱法和差示扫描量热法（DSC）对具有不同比例的进入组分的六种共聚物进行体外降解。具有高含量的乳酸单元的共聚物显示出比富含DXO的共聚物更高的水解速率。共聚物形态也影响降解速率，如无定形和半结晶样品之间的差异所示。研究了电子束灭菌的效果以及使用气相色谱-质谱（GC-MS）技术形成的降解产物。主要降解产物来自酯键断裂。体外降解动力学表明水解复杂，可能是非催化和催化机制的混合物。John Wiley & Sons，Inc.
The degradation of two series of copolymers made of 1,5-dioxepan-2-one (DXO) and L-or D,L-dilactide has been investigated. In vitro degradation of the six copolymers with different ratios of the ingoing components was followed using size exlusion chromatography (SEC), nuclear magnetic resonance (NMR) spectrometry, Fourier transform infrared (FTIR) spectroscopy, and differential scanning calorimetry (DSC). The copolymers with a high content of lactic acid units showed a higher rate of hydrolysis than the DXO-rich copolymers. The copolymer morphology also affects the rate of degradation as seen in the differences between amorphous and semicrystalline samples. The effect of electron beam sterilization was studied as well as the degradation products formed using the gas chromatography-mass spectrometry (GC–MS) technique. The major degradation products resulted from ester bond cleavage. Kinetics of the in vitro degradation indicate a complex hydrolysis, probably a mixture of an uncatalyzed and catalyzed mechanism. © 1994 John Wiley & Sons, Inc.