Unlocking Nanocarriers for the Programmed Release of Antimalarial Drugs
Unlocking Nanocarriers for the Programmed Release of Antimalarial Drugs
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DOI：
10.1002/gch2.201600011
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发表时间：
2017-01
影响因子：
4.9
通讯作者：
A. Bagheri;S. Agarwal;J. Golenser;A. Greiner
中科院分区：
文献类型：
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作者：
A. Bagheri;S. Agarwal;J. Golenser;A. Greiner
提出了一种可编程释放系统，具有从纤维纳米载体（NFN）中释放抗疟青蒿素（ART）的多种释放曲线。这是在疏水性药物洗脱纳米载体输注系统中使用负载 ART 的 NFN 的新范例实现的，适合临床应用。非常重要的是，在这些条件下，ART 并没有像在溶液中观察到的那样降解。
A programmable release system with wide range of release profiles of the antimalarial artemisone (ART) from fibrous nanocarriers (NFN) is presented. This is achieved following a new paradigm of using ART‐loaded NFN in infusion system of hydrophobic drug eluting nanocarriers, adapted to clinical applications. Very importantly, under these conditions ART did not degrade as it was observed in solution.