Morphological studies on the margin of gastric corpus wounds in the rat.
Morphological studies on the margin of gastric corpus wounds in the rat.
复制标题
大鼠胃体伤口边缘的形态学研究。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
Helander Hf
中科院分区：
文献类型：
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作者：
Helander Hf
将成年大鼠胃体浆膜短暂暴露于80%乙酸中，导致其下方粘膜出现伤口。 2、3、6、10、14或21天后处死大鼠，并准备伤口边缘用于光学和电子显微镜检查。边缘腺囊性扩张，胃凹深度增加。表面的许多粘液细胞含有大的脂滴。酶原细胞失去了大部分分泌颗粒，腺体底部开始被粘液细胞占据。壁细胞中的管状囊泡消失，线粒体的体积密度从34%减少到23%。分泌小管也变得比正常小。上皮细胞的形态变化非常明显，分泌能力可能受损。对伤口边缘表面的测量显示，受刺激的大鼠的 pH 值呈中性，表明壁细胞已停止分泌酸。
The serosa of gastric corpus in adult rats was briefly exposed to 80% acetic acid, and as a result wounds appeared in the subjacent mucosa. The rats were killed 2, 3, 6, 10, 14 or 21 days later, and the wound margins were prepared for light and electron microscopy. The marginal glands became cystically dilated, and the gastric pits increased in depth. Many of the mucous cells at the surface contained large lipid droplets. The zymogen cells lost most of their secretory granules and the bottom of the glands became dominated by mucous cells. The tubulo-vesicles disappeared from the parietal cells, and the volume density of mitochondria was reduced from 34% to 23%. The secretory canaliculi also became smaller than normal. The morphological changes in the epithelial cells were so marked that the secretory capacity might be impaired. Measurements on the surface of the wound margins showed neutral pH in stimulated rats, indicating that the parietal cells had discontinued their secretion of acid.