A Fast Experimental Scanner for Proton CT: Technical Performance and First Experience with Phantom Scans.
A Fast Experimental Scanner for Proton CT: Technical Performance and First Experience with Phantom Scans.
复制标题
DOI：
10.1109/tns.2015.2491918
复制
发表时间：
2016-02
影响因子：
1.8
通讯作者：
Zatserklyaniy A
中科院分区：
文献类型：
--
作者：
Johnson RP;Bashkirov V;DeWitt L;Giacometti V;Hurley RF;Piersimoni P;Plautz TE;Sadrozinski HF;Schubert K;Schulte R;Schultze B;Zatserklyaniy A
我们报告了一种用于头部大小物体的质子计算机断层扫描（pCT）的断层扫描仪的设计、制造和首次测试。经过广泛的临床前测试，pCT旨在用于支持质子治疗治疗计划和治疗前验证的患者接受粒子束治疗。扫描仪由两个硅带望远镜组成，用于跟踪幽灵前后的单个质子，以及一个新型的多级闪烁探测器，用于测量质子的剩余能量和范围的组合，从中我们得出被扫描物体中质子的水等效路径长度（WEPL）。WEPL值集和质子在360°角扫描中穿过物体的相关路径由一个迭代的、可并行的重建算法处理，该算法运行在现代GP-GPU硬件上。为了评估扫描仪的性能，我们用来自洛马琳达大学医学中心的同步加速器和西北医学芝加哥质子中心的IBA回旋加速器的200 MeV质子进行了测试。我们的第一个目标是校准仪器，包括跟踪器通道图和校准以及WEPL校准。然后我们对一系列幽灵进行了第一次CT扫描。非常高的持续数据采集速率，每秒超过100万个质子，允许在不到10分钟内完成完整的360°扫描，并且CATPHAN 404幻影的重建验证了在各种材料中质子相对停止功率的准确重建。
We report on the design, fabrication, and first tests of a tomographic scanner developed for proton computed tomography (pCT) of head-sized objects. After extensive preclinical testing, pCT is intended to be employed in support of proton therapy treatment planning and pre-treatment verification in patients undergoing particle-beam therapy. The scanner consists of two silicon-strip telescopes that track individual protons before and after the phantom, and a novel multistage scintillation detector that measures a combination of the residual energy and range of the proton, from which we derive the water equivalent path length (WEPL) of the protons in the scanned object. The set of WEPL values and the associated paths of protons passing through the object over a 360° angular scan are processed by an iterative, parallelizable reconstruction algorithm that runs on modern GP-GPU hardware. In order to assess the performance of the scanner, we have performed tests with 200 MeV protons from the synchrotron of the Loma Linda University Medical Center and the IBA cyclotron of the Northwestern Medicine Chicago Proton Center. Our first objective was calibration of the instrument, including tracker channel maps and alignment as well as the WEPL calibration. Then we performed the first CT scans on a series of phantoms. The very high sustained rate of data acquisition, exceeding one million protons per second, allowed a full 360° scan to be completed in less than 10 minutes, and reconstruction of a CATPHAN 404 phantom verified accurate reconstruction of the proton relative stopping power in a variety of materials.