Engineering hydrogels as extracellular matrix mimics.
Engineering hydrogels as extracellular matrix mimics.
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DOI：
10.2217/nnm.10.12
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发表时间：
2010-04
期刊：
影响因子：
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通讯作者：
Demirci U
中科院分区：
文献类型：
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作者：
Geckil H;Xu F;Zhang X;Moon S;Demirci U
细胞外基质（ECM）是由蛋白质、蛋白多糖和其他可溶性分子组成的复杂细胞环境。ECM为哺乳动物细胞提供结构支持和具有多种重要细胞功能的调节环境，包括将细胞组装成各种组织和器官，调节生长和细胞-细胞通讯。需要开发一种定制的体外细胞培养环境，其模拟天然ECM的复杂和有组织的纳米级网络。最近的研究表明，水凝胶模拟天然ECM的潜力。这种工程化的天然样ECM更有可能为细胞提供诊断和治疗研究的合理线索。对新型生物材料的研究已经导致用于制造用于组织工程和再生医学应用的仿生水凝胶支架的范围和技术的扩展。在这篇文章中，我们详细介绍了当前最先进的工程方法，以创建细胞封装水凝胶组织结构的进展，以及它们在生物医学体外模型中的应用。
Extracellular matrix (ECM) is a complex cellular environment consisting of proteins, proteoglycans, and other soluble molecules. ECM provides structural support to mammalian cells and a regulatory milieu with a variety of important cell functions, including assembling cells into various tissues and organs, regulating growth and cell–cell communication. Developing a tailored in vitro cell culture environment that mimics the intricate and organized nanoscale meshwork of native ECM is desirable. Recent studies have shown the potential of hydrogels to mimic native ECM. Such an engineered native-like ECM is more likely to provide cells with rational cues for diagnostic and therapeutic studies. The research for novel biomaterials has led to an extension of the scope and techniques used to fabricate biomimetic hydrogel scaffolds for tissue engineering and regenerative medicine applications. In this article, we detail the progress of the current state-of-the-art engineering methods to create cell-encapsulating hydrogel tissue constructs as well as their applications in in vitro models in biomedicine.