Dendritic cells and complement: at the cross road of innate and adaptive immunity
Dendritic cells and complement: at the cross road of innate and adaptive immunity
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DOI：
10.1016/j.molimm.2004.03.018
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发表时间：
2004-06-01
影响因子：
3.6
通讯作者：
van Kooten, C
中科院分区：
文献类型：
--
作者：
Castellano, G;Woltman, AM;van Kooten, C
免疫系统不同组成部分之间的相互作用在免疫反应的整体发展中起着关键作用。树突状细胞（Dendritic cells，DCs）和补体是天然免疫的重要组成部分。它们已被证明在诱导适应性免疫应答和维持耐受性方面都相关。然而，这些系统的过度活跃也已被证明是有害的，在各种疾病state.despite增加了解树突状细胞的生物学，相对知之甚少树突状细胞和补体之间可能的相互作用。这篇评论重点关注新的发现，这些发现已经开始揭示先天免疫系统中这些有趣的组成部分。(C)2004 Elsevier Ltd.保留所有权利。
The interaction between different components of the immune system plays a pivotal role in the overall development of immune responses. Dendritic cells (DCs) and complement are essential components of innate immunity. They have been shown to be relevant both in the induction of adaptive immune responses and in maintenance of tolerance. However, hyperactivity of these systems has also been demonstrated to be detrimental in various disease states.Despite increased insight into dendritic cell biology, relatively little is known about possible interactions between dendritic cells and complement. This review focuses on novel findings, which have started to shed light on these intriguing components of the innate immune system. (C) 2004 Elsevier Ltd. All rights reserved.