Anti-Programmed Cell Death Protein 1 (PD-1) Immunotherapy for Metastatic Hepatocellular Carcinoma After Liver Transplantation: A Report of Three Cases.

Anti-Programmed Cell Death Protein 1 (PD-1) Immunotherapy for Metastatic Hepatocellular Carcinoma After Liver Transplantation: A Report of Three Cases.
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抗PD-1免疫治疗肝移植后转移性肝癌3例

DOI:
10.7759/cureus.11150
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发表时间:
2020-10-25
期刊:
Cureus
影响因子:
--
通讯作者:
Morere JF
Morere JF
中科院分区:
其他
文献类型:
--
作者:
Al Jarroudi O;Ulusakarya A;Almohamad W;Afqir S;Morere JF

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由于缺乏有效的治疗方案,肝移植术后复发性肝细胞癌(HCC)的治疗是困难的。肝移植中新兴免疫疗法的现有证据是基于轶事经验,需要额外的调查。为了确定免疫治疗在肝移植受者中的有效性和安全性,我们报告了3例肝移植后复发性转移性HCC患者,他们接受了nivolumab作为标签外挽救治疗。
The treatment of recurrent hepatocellular carcinoma (HCC) after liver transplantation is difficult due to the lack of effective treatment options. The available evidence on the emerging immunotherapy in liver transplantation is based on anecdotal experiences and requires additional investigations. To determine the efficacy and safety of immunotherapy in liver transplant recipients, we report three cases of recurrent metastatic HCC after liver transplantation who were treated with nivolumab as off-label salvage therapy.
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