The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours
The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours
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DOI：
10.1002/path.1067
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发表时间：
2002-04-01
影响因子：
7.3
通讯作者：
Tomlinson, IPM
中科院分区：
文献类型：
--
作者：
Sawyer, EJ;Hanby, AM;Tomlinson, IPM
在以前的叶状肿瘤的研究中，已经表明，基质和上皮细胞可以表现出不同的分子变化，这表明两者都是肿瘤过程的一部分。鉴于这一发现，决定通过检查Wnt-APC-β-连环蛋白途径来研究这些肿瘤中的基质-上皮相互作用。对119个叶状肿瘤进行β-连环蛋白和细胞周期蛋白D1免疫组化。86例（72%）显示间质细胞核β-连环蛋白定位，57%的染色为中度或强染色;然而，在该系列的8例恶性肿瘤中，7例显示细胞核染色缺失或弱染色（p < 0.025）。在没有肿瘤细胞核β-连环蛋白染色中看到的上皮成分。中度或重度间质细胞周期蛋白D I染色与核间质β-连环蛋白染色相关（p
In a previous study of phyllodes tumours, it has been shown that both the stroma and the epithelium can exhibit distinct molecular changes, suggesting that both are part of the neoplastic process. In view of this finding, it was decided to study stromal-epithelial interactions in these tumours by examining the Wnt-APC-beta-catenin pathway. beta-catenin and cyclin D1 immunohistochemistry was performed on 119 phyllodes tumours. Eighty-six (72%) showed stromal nuclear beta-catenin localization and in 57%, the staining was moderate or strong; however, of the eight malignant tumours in the series, seven showed absent or weak nuclear staining (p < 0.025). In no tumour was nuclear beta-catenin staining seen in the epithelial component. Moderate or strong stromal cyclin D I staining correlated with nuclear stromal beta-catenin staining (p