Retuning of inferior colliculus neurons following spiral ganglion lesions: a single-neuron model of converging inputs.
Retuning of inferior colliculus neurons following spiral ganglion lesions: a single-neuron model of converging inputs.
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DOI：
10.1007/s10162-008-0139-6
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发表时间：
2009-03
影响因子：
2.4
通讯作者：
Snyder, Russell L.
中科院分区：
文献类型：
--
作者：
Sumner, Christian J.;Scholes, Chris;Snyder, Russell L.
螺旋神经节细胞，代表一个有限的部门的听觉神经阵列的病变，产生立即的变化，在下丘（IC）神经元的频率调谐。在损伤频率处失去兴奋，但对相邻频率的反应保持不变，并出现新的活动区域。这导致调音和音调位置进展的立即变化。在不同的外周损伤方法和其他核团的听觉神经元中也观察到类似的效果。这些损伤后变化的机制尚不清楚，但在IC中观察到的急性效应强烈表明，通过消除抑制，潜在输入被“揭开”。在这项研究中，我们探讨了计算模型的单个神经元的兴奋性和抑制性输入的收敛范围内的特征频率（CF），它可以模拟狭窄的损伤前调谐IC神经元，并占CF调谐病变后的变化。如果输入沿着模型IC神经元的树突以精确的顺序相对于彼此对齐，则模型可以再现数据。这些神经元的频率调谐近似于生理学上看到的。去除代表窄频率范围的输入导致先前阈下兴奋性输入的暴露，这导致CF的变化。相反，如果所有的输入都会聚在细胞体上的同一点，则感受野很宽，并且暴露很少导致CF变化。然而，如果抑制是紧张性的，没有刺激驱动的成分，那么暴露仍然可以产生CF的变化。
Lesions of spiral ganglion cells, representing a restricted sector of the auditory nerve array, produce immediate changes in the frequency tuning of inferior colliculus (IC) neurons. There is a loss of excitation at the lesion frequencies, yet responses to adjacent frequencies remain intact and new regions of activity appear. This leads to immediate changes in tuning and in tonotopic progression. Similar effects are seen after different methods of peripheral damage and in auditory neurons in other nuclei. The mechanisms that underlie these postlesion changes are unknown, but the acute effects seen in IC strongly suggest the “unmasking” of latent inputs by the removal of inhibition. In this study, we explore computational models of single neurons with a convergence of excitatory and inhibitory inputs from a range of characteristic frequencies (CFs), which can simulate the narrow prelesion tuning of IC neurons, and account for the changes in CF tuning after a lesion. The models can reproduce the data if inputs are aligned relative to one another in a precise order along the dendrites of model IC neurons. Frequency tuning in these neurons approximates that seen physiologically. Removal of inputs representing a narrow range of frequencies leads to unmasking of previously subthreshold excitatory inputs, which causes changes in CF. Conversely, if all of the inputs converge at the same point on the cell body, receptive fields are broad and unmasking rarely results in CF changes. However, if the inhibition is tonic with no stimulus-driven component, then unmasking can still produce changes in CF.
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