The effect of polymerized placenta hemoglobin on renal ischemia/reperfusion injury

The effect of polymerized placenta hemoglobin on renal ischemia/reperfusion injury
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DOI：
10.3109/10731199.2012.696062
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发表时间：
2012-11
期刊：
Artificial Cells, Blood Substitutes, and Biotechnology
影响因子：
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通讯作者：
Tao Li;Zhenyu Zhang;D. Liao;Yanfang Chen;Chengmin Yang;Xuewen Xu;Jin Liu
Tao Li;Zhenyu Zhang;D. Liao;Yanfang Chen;Chengmin Yang;Xuewen Xu;Jin Liu
中科院分区：
其他
文献类型：
--
作者：
Tao Li;Zhenyu Zhang;D. Liao;Yanfang Chen;Chengmin Yang;Xuewen Xu;Jin Liu

文献摘要

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摘要本研究的目的是探讨血红蛋白氧载体（HBOC）是否减轻缺血/再灌注（I/R）引起的肾损伤。雄性SD大鼠随机分为假手术组（Sham）、缺血再灌注组（I/R）和HBOC组（注射0.1gHb/kg PolyPHb）。双侧肾蒂交叉夹闭45 min造成缺血。然后释放钳夹以允许24小时再灌注。在不升高血压的情况下，PolyPHb可降低血尿素氮和血浆肌酐，降低肾组织肿瘤坏死因子-α和白细胞介素-8。因此，我们的研究结果表明，PolyPHb可以减轻I/R损伤后的肾损伤，这种作用可能与抑制炎症反应有关。
Abstract The goal of this study was to investigate whether hemoglobin-based oxygen carrier (HBOC) attenuated ischemia/reperfusion (I/R)-induced kidney injury. Male SD rats were randomly divided into a sham group, I/R group, and HBOC group (injection of 0.1 gHb/kg PolyPHb). The ischemia was induced by bilateral renal pedicle cross-clamping for 45min. Then the clamp was released to allow 24h reperfusion. Without increasing blood pressure, PolyPHb reduced the blood urea nitrogen and creatinine in plasma and attenuated the tumor necrosis factor-α and interleukin-8 in kidney tissue. Therefore, our findings suggest that PolyPHb could reduce kidney injury after I/R injury, and this effect was probably associated with the depressed inflammatory response.