Breath hydrogen test in the diagnosis of environmental enteropathy in children living in an urban slum
Breath hydrogen test in the diagnosis of environmental enteropathy in children living in an urban slum
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DOI：
10.1007/s10620-006-9288-9
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发表时间：
2007-05-01
影响因子：
3.1
通讯作者：
Fagundes-Neto, Ulysses
中科院分区：
文献类型：
--
作者：
dos Reis, Jairo Cesar;de Morais, Mauro Batista;Fagundes-Neto, Ulysses
本研究的目的是评估呼吸氢测试在诊断与城市贫民窟儿童无症状环境性肠病相关的小肠细菌过度生长中的作用。这项研究包括 50 名生活在贫民窟的学龄儿童和 50 名在同镇一家私人诊所就诊的儿童。在不同天给予乳果糖或葡萄糖后进行呼气氢测试。当收集的样品中氢气浓度增加超过 20 ppm 且持续时间长达 60 分钟时，即可诊断为细菌过度生长。摄入乳果糖后产生的氢气比摄入葡萄糖后产生的氢更多。居住在贫民窟的儿童中有 37.5% 存在细菌过度生长，对照组儿童中有 2.1% 存在细菌过度生长（P < 0.001）。当在呼气氢测试中使用乳果糖时，居住在贫民窟的儿童出现细菌过度生长的比例更高。
The aim of this study was to evaluate the breath hydrogen test in the diagnosis of small intestine bacterial overgrowth associated with asymptomatic environmental enteropathy in children living in an urban slum. Fifty school-age children living in a slum and 50 children who attended a private health clinic in the same town were included in the study. Breath hydrogen test was carried out after the administration of lactulose or glucose on two different days. Bacterial overgrowth was diagnosed when the hydrogen concentration increased more than 20 ppm in a sample collected for up to 60 min. Production of hydrogen was greater after the ingestion of lactulose than after the ingestion of glucose. Bacterial overgrowth was noted in 37.5% of the children living in the slum and in 2.1% of the control group (P < 0.001). The children living in the slum presented a higher proportion of bacterial overgrowth when lactulose was used in the breath hydrogen test.