Colorectal cancer in mice genetically deficient in the mucin Muc2
Colorectal cancer in mice genetically deficient in the mucin Muc2
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DOI：
10.1126/science.1069094
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发表时间：
2002-03-01
期刊：
影响因子：
56.9
通讯作者：
Augenlicht, L
中科院分区：
文献类型：
--
作者：
Velcich, A;Yang, WC;Augenlicht, L
胃肠道由一层粘液组成，该粘液由高度糖基化的蛋白质（称为粘蛋白）组成。为了评估粘蛋白在肠道癌发生中的重要性，我们构建了遗传缺陷 Muc2（最丰富的分泌性胃肠粘蛋白）的小鼠。 Muc2(-/-)小鼠表现出异常的肠隐窝形态以及改变的细胞成熟和迁移。最值得注意的是，小鼠经常在小肠中出现腺瘤，并发展为侵袭性腺癌以及直肠肿瘤。因此，Muc2参与结直肠癌的抑制。
The gastrointestinal tract is tined by a layer of mucus comprised of highly glycosylated proteins called mucins. To evaluate the importance of mucin in intestinal carcinogenesis, we constructed mice genetically deficient in Muc2, the most abundant secreted gastrointestinal mucin. Muc2(-/-) mice displayed aberrant intestinal crypt morphology and altered cell maturation and migration. Most notably, the mice frequently developed adenomas in the small intestine that progressed to invasive adenocarcinoma, as welt as rectal tumors. Thus, Muc2 is involved in the suppression of colorectal cancer.