Diagnostic and prognostic prediction using gene expression profiles in high-dimensional microarray data.
Diagnostic and prognostic prediction using gene expression profiles in high-dimensional microarray data.
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DOI：
10.1038/sj.bjc.6601326
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发表时间：
2003-11-03
影响因子：
8.8
通讯作者：
Simon, R
中科院分区：
文献类型：
--
作者：
Simon, R
DNA微阵列是一种潜在的强大的技术，用于改善诊断分类，治疗选择和治疗药物的开发。然而，在使用微阵列时存在许多潜在的陷阱，导致错误的线索和错误的结论。本文提供了一个审查的关键功能，以观察在发展诊断和预后分类系统的基础上基因表达谱和一些陷阱要知道在阅读报告的微阵列为基础的研究。
DNA microarrays are a potentially powerful technology for improving diagnostic classification, treatment selection and therapeutics development. There are, however, many potential pitfalls in the use of microarrays that result in false leads and erroneous conclusions. This paper provides a review of the key features to be observed in developing diagnostic and prognostic classification systems based on gene expression profiling and some of the pitfalls to be aware of in reading reports of microarray-based studies.