Brain plasticity and tumors
Brain plasticity and tumors
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DOI：
10.1007/978-3-211-72283-1_1
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Duffau, H.
中科院分区：
文献类型：
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作者：
Duffau, H.
大脑可塑性是神经系统在个体发育、学习或受伤后重塑自身的潜力。本文第一部分综述了不同功能水平下可塑性的病理生理机制。这种可塑性潜能意味着人类大脑的解剖功能组织，无论是生理的还是病理的，都具有灵活性。重组的模式可能会根据脑损伤的时间进程而有所不同，在生长较慢的病变中具有较好的功能补偿。本综述的第二部分分析了肿瘤生长和大脑重塑之间的相互作用，使用非侵入性（神经成像）和侵入性（电生理）的功能制图方法。最后，从外科的角度探讨了更好地理解这些大脑再分配机制所提供的治疗意义。增强术前对个体重组潜力的预测可以整合到手术计划中，并通过量身定制的康复计划来优化脑肿瘤切除术后的功能恢复，从而保持生活质量。
Brain plasticity is the potential of the nervous system reshape itself during ontogeny, learning or following injuries. The first part of this article reviews the pathophysiological mechanisms underlying plasticity at different functional levels. Such plastic potential means that the anatomo-functional organization of the brain in humans, both physiological and pathological, has flexibility Patterns of reorganization may differ according to the time-course of cerebral damage, with better functional compensation in more slowly growing lesions. The second part of this review analyzes the interactions between tumor growth and brain reshaping, using non-invasive (neuroimaging) and invasive (electro-physiological) methods of functional mapping. Finally, the therapeutic implications provided by a greater understanding of these mechanisms of cerebral redistribution are explored from a surgical point of view. Enhanced preoperative prediction of an individual's potential for reorganization might be integrated into surgical planning and preserving quality of fife through tailored rehabilitation programmes to optimize functional recovery following resection of a brain tumor.