Pentraxin3 is a novel marker for stent-induced inflammation and neointimal thickening
Pentraxin3 is a novel marker for stent-induced inflammation and neointimal thickening
复制标题
DOI：
10.1016/j.atherosclerosis.2007.05.031
复制
发表时间：
2008-03-01
期刊：
影响因子：
5.3
通讯作者：
Node, Koichi
中科院分区：
文献类型：
--
作者：
Kotooka, Norihiko;Inoue, Teruo;Node, Koichi
损伤血管壁的炎症反应在再狭窄的发生机制中起重要作用。正五聚蛋白3（PTX 3）在炎症部位响应于原发性炎症刺激而合成。为了确定血浆PTX 3水平在损伤血管炎症病理生理学中的临床意义，我们连续测量了20例接受择期冠状动脉支架植入术的患者的水平。冠状动脉支架术后15分钟血浆PTX 3水平升高，24小时在冠状静脉窦（与基线相比P < 0.001）和外周血（与基线相比P < 0.001）中达到最大值。PCI术后15 min时，再狭窄患者的PTX 3跨心梯度高于无再狭窄患者（0.40 +/- 0.64 vs-0.19 +/- 0.33 ng/ml，P = 0.02）。此外，在冠状静脉窦中，24 h时PTX 3的增加与48 h时中性粒细胞表面活化的Mac-1的增加呈正相关（r = 0.48，p < 0.05）。逐步多元回归分析显示，24 h时PTX 3的相对增加是晚期管腔丢失的最有力预测因素（r = 0.547，P = 0.007）。冠状动脉支架植入术增强了与炎症反应相关的循环PTX 3水平。PTX 3可能是评价血管损伤后炎症反应和新生内膜增厚的有用指标。(C)2007爱思唯尔爱尔兰有限公司保留所有权利。
Inflammation in the injured vessl wall plays an essential role in the mechanism of restenosis. Pentraxin3 (PTX3) is synthesized at the inflammatory site in response to primary inflammatory stimuli. To establish the clinical significance of plasma PTX3 levels in the pathophysiology of inflammation in the injured vessels, we serially measured the levels in 20 patients undergoing elective coronary stenting. Plasma PTX3 levels increased 15 min after coronary stenting, and reached a maximum at 24 h in the coronary sinus (P < 0.001 versus baseline) and peripheral blood (P < 0.001 versus baseline). The transcardiac gradient of PTX3 at 15 min after PCI was higher in patients with than those without restenosis (0.40 +/- 0.64 versus -0.19 +/- 0.33 ng/ml, P = 0.02). Furthermore, the increase in PTX3 at 24 h was positively correlated with the increase in activated Mac-1 on the surface of neutrophils at 48 h (r = 0.48, p < 0.05) in the coronary sinus. Stepwise multiple regression analysis demonstrated that the relative increase in PTX3 at 24 h was the most powerful predictor of late lumen loss (r = 0.547, P = 0.007). Coronary stenting enhanced circulating PTX3 levels in association with an inflammatory response. PTX3 may be a useful marker for evaluation of inflammatory reaction and neointimal thickening after vascular injury. (C) 2007 Elsevier Ireland Ltd. All rights reserved.