One-Year Cardiovascular Event Rates in Japanese Outpatients With Myocardial Infarction, Stroke, and Atrial Fibrillation - Results From the Japan Thrombosis Registry for Atrial Fibrillation, Coronary, or Cerebrovascular Events (J-TRACE)
One-Year Cardiovascular Event Rates in Japanese Outpatients With Myocardial Infarction, Stroke, and Atrial Fibrillation - Results From the Japan Thrombosis Registry for Atrial Fibrillation, Coronary, or Cerebrovascular Events (J-TRACE)
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DOI：
10.1253/circj.cj-11-0378
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发表时间：
2011-11-01
影响因子：
3.3
通讯作者：
Kobayashi, Hiroyuki
中科院分区：
文献类型：
--
作者：
Goto, Shinya;Ikeda, Yasuo;Kobayashi, Hiroyuki
背景：在日本，有心肌梗死(MI)、中风和房颤病史的稳定性门诊患者发生心血管事件的风险仍然存在不确定性。方法和结果：在日本房颤、冠状动脉或脑血管事件血栓登记(J-TRACE)中，有心肌梗塞(n=2,291)、中风(n=3,554)和/或心房颤动(n=2,242)病史的全国稳定性门诊患者的1年随访数据为7,513例(随访率：92.9%)。主要终点(死亡/心肌梗死/中风)在1年内每100人年报告3.53起事件(95%可信区间[CI]：3.11-3.99)。1年内全因死亡率为1.35(95%CI：1.10~1.65)，卒中死亡率为0.15(95%CI：0.08~0.27)，MI死亡率为0.06(95%CI：0.02~0.14)/100人年。非致死性卒中发生率为1.85(95%CI：1.55~2.19)，非致死性MI发生率为0.33(95%CI：0.21~0.49)。非致命性中风的发生率在中风患者中最高(2.95；95%CI：2.39-3.60/100人年)，而非致命性心肌梗死在所有疾病类别中的发生率相似。研究者决定每100人年发生0.21例严重非致命性出血事件(95%可信区间：0.12-0.34)。结论：在这个庞大的全国性日本登记中，有卒中病史的患者发生卒中事件的比例最高。(保监会J 2011；75：2598-2604)
Background: There remains uncertainty about the risk of cardiovascular events in stable outpatients with a history of myocardial infarction (MI), stroke, and atrial fibrillation in Japan.Methods and Results: In the Japan Thrombosis Registry for Atrial Fibrillation, Coronary, or Cerebrovascular Events (J-TRACE), a nationwide prospective cohort of stable outpatients with a history of MI (n=2,291), stroke (n=3,554), and/or atrial fibrillation (n=2,242), 1-year follow-up data were available for 7,513 of 8,087 patients (follow-up rate: 92.9%). The primary endpoint (death/MI/stroke) was reported in 3.53 events per 100 person-years (95% confidence interval [Cl]: 3.11-3.99) within 1 year. The rates of all-cause death, death from stroke, and death from MI within 1 year were 1.35 (95%CI: 1.10-1.65), 0.15 (95%CI: 0.08-0.27), and 0.06 (95%CI: 0.02-0.14) per 100 person-years, respectively. The rate of non-fatal stroke was 1.85 (95%CI: 1.55-2.19), while that of non-fatal MI was 0.33 (95%CI: 0.21-0.49). The rate of non-fatal stroke was highest among stroke patients (2.95; 95%CI: 2.39-3.60 per 100 person-years), while that of non-fatal MI was similar across all disease categories. Investigator-decided serious non-fatal bleeding events occurred in 0.21 events (95%CI: 0.12-0.34) per 100 person-years.Conclusions: In this large, nationwide Japanese registry, the highest stroke event rate was seen in patients with a history of stroke. (Circ J 2011; 75: 2598-2604)