PROMOTION OF WOUND REPAIR IN OLD MICE BY LOCAL INJECTION OF MACROPHAGES
PROMOTION OF WOUND REPAIR IN OLD MICE BY LOCAL INJECTION OF MACROPHAGES
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DOI：
10.1073/pnas.86.6.2018
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发表时间：
1989-03-01
影响因子：
11.1
通讯作者：
ROTH, GS
中科院分区：
文献类型：
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作者：
DANON, D;KOWATCH, MA;ROTH, GS
腹腔巨噬细胞应用于老年小鼠实验诱导的皮肤伤口，加速愈合至几乎与未治疗的年轻动物相当的水平。与老年供体相比，从年轻供体获得巨噬细胞时，观察到的加速略大。这些发现与巨噬细胞功能缺陷作为衰老中伤口愈合受损的原因一致，并提出了可能的治疗策略。
Application of peritoneal macrophages to experimentally induced cutaneous wounds of old mice accelerates healing to levels almost comparable to those of untreated young animals. Slightly greater acceleration is observed when macrophages are obtained from young as opposed to old donors. These findings are consistent with a defect in macrophage function as a cause of impaired wound healing in senescence and suggest a possible therapeutic strategy.