Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment.
Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment.
复制标题
DOI：
10.1038/s41598-021-91091-9
复制
发表时间：
2021-06-03
影响因子：
4.6
通讯作者：
Pizzagalli DA
中科院分区：
文献类型：
--
作者：
Kangas BD;Iturra-Mena AM;Robble MA;Luc OT;Potter D;Nickels S;Bergman J;Carlezon WA Jr;Pizzagalli DA
神经精神疾病治疗开发的挑战部分归因于缺乏能够捕获临床人群和实验动物相关表型的转化模型。触摸感应程序越来越多地用于开发创新的动物模型，以更好地符合人类参与者使用的测试条件。此外，电生理学技术的进步已经确定了与神经精神疾病特征相关的神经生理学特征。目前的研究通过基于人类脑电图（EEG）认知控制研究中使用的反向翻译协议开发大鼠侧翼任务和电生理记录来整合这些方法。评估了各种基于触摸屏的刺激有效获得刺激控制和推进侧翼测试的能力。然后检查优化的刺激是否在局部场电位 (LFP) 线和脑电图颅骨螺钉上引发原型视觉诱发电位 (VEP)。在评估的刺激中，紫色和绿色摄影刺激与有效训练和预期的侧翼干扰效果相关。在 LFP 和 EEG 记录的 VEP 中也观察到有序的刺激锁定结果。这些研究与其他研究一起验证了并发电生理记录和基于啮齿动物触摸屏的认知测试的可行性，并鼓励未来在治疗开发中使用这种综合方法。
Challenges in therapeutics development for neuropsychiatric disorders can be attributed, in part, to a paucity of translational models capable of capturing relevant phenotypes across clinical populations and laboratory animals. Touch-sensitive procedures are increasingly used to develop innovative animal models that better align with testing conditions used in human participants. In addition, advances in electrophysiological techniques have identified neurophysiological signatures associated with characteristics of neuropsychiatric illness. The present studies integrated these methodologies by developing a rat flanker task with electrophysiological recordings based on reverse-translated protocols used in human electroencephalogram (EEG) studies of cognitive control. Various touchscreen-based stimuli were evaluated for their ability to efficiently gain stimulus control and advance to flanker test sessions. Optimized stimuli were then examined for their elicitation of prototypical visual evoked potentials (VEPs) across local field potential (LFP) wires and EEG skull screws. Of the stimuli evaluated, purple and green photographic stimuli were associated with efficient training and expected flanker interference effects. Orderly stimulus-locked outcomes were also observed in VEPs across LFP and EEG recordings. These studies along with others verify the feasibility of concurrent electrophysiological recordings and rodent touchscreen-based cognitive testing and encourage future use of this integrated approach in therapeutics development.
登录
查看更多内容
影响因子：
3.5
作者：
Meier PM;Reinagel P
通讯作者：
Reinagel P
影响因子：
3.7
作者：
Danielmeier, Claudia;Wessel, Jan R.;Ullsperger, Markus
通讯作者：
Ullsperger, Markus
DOI：
10.1073/pnas.1308198110
发表时间：
2013-09-03
影响因子：
11.1
作者：
DePoy, Lauren;Daut, Rachel;Holmes, Andrew
通讯作者：
Holmes, Andrew
影响因子：
2.9
作者：
Hasselmo, ME;Bodelón, C;Wyble, BP
通讯作者：
Wyble, BP
影响因子：
4.1
作者：
GRATTON, G;COLES, MGH;DONCHIN, E
通讯作者：
DONCHIN, E