Role of extracellular vesicles during oocyte maturation and early embryo development.
Role of extracellular vesicles during oocyte maturation and early embryo development.
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DOI：
10.1071/rd19389
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
da Silveira, J C
中科院分区：
文献类型：
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作者：
de Avila, A C F C M;da Silveira, J C
卵泡是卵巢中卵母细胞发育的动态微环境。卵泡内体细胞和卵母细胞之间的细胞间交流是产生合格配子的必要条件。细胞外囊泡是细胞分泌的纳米颗粒，在卵泡微环境中介导细胞间的通讯，可以从卵泡液中获得。这些细胞外囊泡作为生物标志物和辅助生殖技术中模拟生理条件的补充工具被研究，因为它们是生物活性分子的载体。因此，本文综述了卵泡变化的重要性以及卵泡液细胞外囊泡在卵母细胞成熟和早期胚胎发育中的作用。最后，我们建议考虑细胞外囊泡的来源，以改善诊断方法和增加体外胚胎的产生。
The follicle is a dynamic microenvironment in the ovary where the oocyte develops. Intercellular communication between somatic cells and the oocyte inside the follicle is essential to generate a competent gamete. Extracellular vesicles are nanoparticles secreted by cells that mediate cell-to-cell communication in the follicle microenvironment and can be obtained from the follicular fluid. These extracellular vesicles have been studied as biomarkers and supplementation tools to mimic physiological conditions during assisted reproductive techniques because they are vehicles of bioactive molecules. Therefore, this paper reviews the importance of changes in the ovarian follicle and the effects of extracellular vesicles from follicular fluid during oocyte maturation and early embryo development. Finally, we propose that is important to consider the source of the extracellular vesicles to improve diagnostic methods and to increase invitro embryo production.