Electrocardiographic conduction disturbances in association with low-level lead exposure (the normative aging study)
Electrocardiographic conduction disturbances in association with low-level lead exposure (the normative aging study)
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DOI：
10.1016/s0002-9149(98)00402-0
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发表时间：
1998-09-01
影响因子：
2.8
通讯作者：
Hu, H
中科院分区：
文献类型：
--
作者：
Cheng, YW;Schwartz, J;Hu, H
最近的研究表明，铅的累积暴露可能比以前认为的更具毒性。这是为了研究低铅暴露与心电图（ECG）传导障碍之间的关系，775名男性参加了规范性老龄化研究（平均年龄68岁，范围48至93）。我们使用K-X射线荧光测量胫骨和髌骨中的铅水平，并使用石墨炉原子吸收光谱法测量血铅水平。血铅、胫骨铅和髌骨铅的平均（SD）值分别为5.8（3.4）μ g/dl、22.2（13.4）μ g/g和30.8（19.2）μ g/g。骨铅水平与心率校正QT和QRS间期呈正相关，尤其是在年轻男性中。特别是在男性中
Recent research indicates that cumulative exposure to lead may be more toxic than previously thought. This was undertaken to examine the relation of low-lead exposure to electrocardiographic (ECG) conduction disturbances among 775 men who participated in the Normative Aging Study (average age 68 years; range 48 to 93). We used K-x-ray fluorescence to measure lead levels in the tibia and patella, and graphite furnace atomic absorption spectroscopy to measure blood lead levels. The mean (SD) values for blood lead, tibia lead, and patella lead were 5.8 (3.4) mu g/dl, 22.2 (13.4) mu g/g, and 30.8 (19.2) mu g/g, respectively. Bone lead levels were found to be positively associated with heart rate-corrected QT and QRS intervals, especially in younger men. Specifically, in men