Neuronal adhesion and synapse organization in recovery after brain injury.
Neuronal adhesion and synapse organization in recovery after brain injury.
复制标题
DOI：
10.2217/fnl.13.35
复制
发表时间：
2013-09
期刊：
影响因子：
1.3
通讯作者：
Biederer T
中科院分区：
文献类型：
--
作者：
Park K;Biederer T
尽管中风或创伤性脑损伤普遍存在，但很少有特定的治疗靶点来管理脑损伤。对于创伤性脑损伤，特征性神经元变化包括轴突肿胀和变性，以及突触（神经元之间的通讯部位）的丧失。随后是轴突发芽和突触标志物的改变。由此产生的神经元连接的变化可能有助于创伤性脑损伤对认知功能的影响，并且潜在的机制可能代表治疗干预的要点。与此一致的是，动物研究暗示了组织突触的粘附和信号分子是神经元恢复的分子参与者。在这篇文章中，作者重点讨论了细胞表面相互作用在人类和动物脑损伤后恢复中的作用。作者回顾了损伤时细胞和突触的改变，以及细胞粘附、蛋白表达和修饰的变化如何参与恢复。神经元表面相互作用的变化作为潜在的目标和它们可能的价值为治疗的发展也进行了讨论。
Few specific therapeutic targets exist to manage brain injury, despite the prevalence of stroke or traumatic brain injury. With traumatic brain injury, characteristic neuronal changes include axonal swelling and degeneration, and the loss of synapses, the sites of communication between neurons. This is followed by axonal sprouting and alterations in synaptic markers in recovery. The resulting changes in neuronal connectivity are likely to contribute to the effects of traumatic brain injury on cognitive functions and the underlying mechanisms may represent points of therapeutic intervention. In agreement, animal studies implicate adhesion and signaling molecules that organize synapses as molecular players in neuronal recovery. In this article, the authors focus on the role of cell surface interactions in the recovery after brain injury in humans and animals. The authors review cellular and synaptic alterations that occur with injury and how changes in cell adhesion, protein expression and modification may be involved in recovery. The changes in neuronal surface interactions as potential targets and their possible value for the development of therapeutics are also discussed.