Nimodipine potentiates the light-induced suppression of melatonin.
Nimodipine potentiates the light-induced suppression of melatonin.
复制标题
尼莫地平增强光诱导的褪黑激素抑制作用。
DOI：
10.1016/s0304-3940(99)00554-6
复制
发表时间：
1999
影响因子：
2.5
通讯作者：
Zee,PC
中科院分区：
文献类型：
--
作者：
Benloucif,S;Bauer,GL;Dubocovich,ML;Finkel,SI;Zee,PC
在哺乳动物中，通过给予钙通道拮抗剂尼莫地平可以增强昼夜节律钟对光的相移反应。在本研究中，我们评估了尼莫地平的潜力，影响人体生物钟对光的反应，通过测量光诱导的血浆中褪黑激素水平的抑制。7名健康的年轻受试者（3名男性，4名女性，27.3±1.8岁）四次入住西北大学医学院的临床研究中心。在夜间收集血液以评估尼莫地平（30 mg，口服，01：30 h）在存在或不存在光（500 lux，2-3 am）的情况下对血浆褪黑激素水平的影响。用放射免疫法测定血浆褪黑素水平。暴露于光1小时抑制褪黑激素水平在血浆中的近38%，相对于在同一时间在没有光的情况下获得的样品（P=0.013）。尼莫地平管理没有改变血浆褪黑激素水平。然而，尼莫地平和光的联合治疗抑制了血浆中褪黑激素水平的59%。尼莫地平和光照治疗后血浆褪黑激素水平显著低于安慰剂/光照治疗后（P=0.014）。因此，钙通道拮抗剂尼莫地平增强光对血浆中褪黑激素水平的抑制作用。这些结果表明，钙离子通道拮抗剂尼莫地平也可能增强人体生物钟对光的反应，因此可能与光疗结合用于治疗睡眠和昼夜节律紊乱。
In mammals the phase shifting response of the circadian clock to light can be enhanced by administration of the calcium channel antagonist nimodipine. In the present study we assessed the potential for nimodipine to affect the responsiveness of the human circadian clock to light by measuring the light-induced suppression of melatonin levels in plasma. Seven healthy young subjects (3M, 4F, 27.3±1.8 years old) were admitted on four occasions to the Clinical Research Center at Northwestern University Medical School. Blood was collected during the night to assess the effect of nimodipine (30 mg, orally, 01:30 h) on plasma melatonin levels in the presence or absence of light (500 lux, 2–3 am). Melatonin levels in plasma were measured by radioimmunoassay. Exposure to light for 1 h suppressed melatonin levels in plasma by nearly 38% relative to samples obtained at the same time in the absence of light (P=0.013). Nimodipine administration did not modify plasma melatonin levels. However, combined treatment with nimodipine and light suppressed melatonin levels in plasma by 59%. Levels of plasma melatonin were significantly lower following treatment with nimodipine and light than following treatment with placebo/light (P=0.014). Thus, the calcium channel antagonist nimodipine potentiated the suppressive effect of light on melatonin levels in plasma. These results suggest that the calcium channel antagonist nimodipine may also potentiate the response of the human circadian clock to light, and might thus be useful in combination with phototherapy for the treatment of sleep and circadian rhythm disorders.