EVIDENCES OF VASCULAR OCCLUSION IN MULTIPLE SCLEROSIS AND ENCEPHALOMYELITIS
EVIDENCES OF VASCULAR OCCLUSION IN MULTIPLE SCLEROSIS AND ENCEPHALOMYELITIS
复制标题
多发性硬化症和脑脊髓炎中血管闭塞的证据
DOI：
--
复制
发表时间：
1937
期刊：
影响因子：
--
通讯作者：
T. J. Putnam
中科院分区：
文献类型：
--
作者：
T. J. Putnam
最近的实验工作表明，多发性硬化症的病变和“弥散性脑脊髓炎”的病变似乎可能是由局部循环障碍引起的，这种循环障碍显然具有静脉侧阻塞的性质。“弥散性脑脊髓炎”似乎代表了同一过程的较急性阶段。根据这一观点，中枢神经系统血管的内容物，或者可能是内膜的内容物，必须有一个原发性的改变，从而导致小静脉血栓形成。这产生局部被动充血和轻度退行性过程，对髓鞘的影响大于其他结构。髓鞘退化并被吞噬。“炎症”现象将被认为是继发性或症状性的，而胶质瘤是修复性或反应性的。显然，只要这个假设建立在实验结果的基础上，它在很大程度上仍然是一种推测
Recent experimental work1has made it seem probable that the lesions of multiple sclerosis and also those of the forms of "disseminated encephalomyelitis" which seem to represent a more acute stage of the same process2are produced by a local circulatory disturbance, apparently of the nature of an obstruction on the venous side. According to this point of view, there must be a primary change in the contents of the vessels of the central nervous system, or possibly of the intimal lining, which leads to thrombosis of venules. This produces local passive congestion and a mild degenerative process which affects myelin sheaths more than other structures. The myelin degenerates and is phagocytosed. The "inflammatory" phenomena would then be regarded as secondary or symptomatic and the gliosis as reparative or reactive. This hypothesis obviously must remain largely a speculation as long as it rests on the results of experimentation