Synthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes
Synthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes
复制标题
两种新型有机钌(II)配合物的合成、结构表征和细胞毒活性
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
T. Sabo
中科院分区：
文献类型：
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作者：
S. Grgurić;M. Arbi;M. Alshtewi;D. Jeremic;G. Kalud̄erović;S. Gómez‐Ruiz;Ž. Žižak;Z. Juranić;T. Sabo
以(η6-p-伞花烃)2RuCl2(η6-p-伞花烃)2RuCl2(CH3NH(CH2)4NH)Pf6或维生素K3-缩氨基硫脲((η6-p-伞花烃)RuCl2(K3tsc))为起始配体，合成了两个新的含N-甲基哌嗪的Ru(II)配合物。通过元素分析、红外光谱、电子吸收光谱和核磁共振光谱对其结构进行了表征。化合物1的X-射线晶体结构测定揭示了“琴凳”几何构型。从配体的角度讨论了两种配合物细胞毒活性的差异。
Two new p-cymene ruthenium(II) complexes containing as additional ligands N-methylpiperazine (((η 6 -p-cymene)RuCl2(CH3NH(CH2)4NH))PF6, com- plex 1) or vitamin K3-thiosemicarbazone (((η 6 -p-cymene)RuCl2(K3tsc)), com- plex 2) were synthesized starting from ((η 6 -p-cymene)2RuCl2)2 and the cor- responding ligand. The complexes were characterized by elemental analysis, IR, electronic absorption and NMR spectroscopy. The X-ray crystal structure de- termination of complex 1 revealed "piano-stool" geometry. The differences in the cytotoxic activity of the two complexes are discussed in terms of the ligand
影响因子：
15
作者：
Chen, HM;Parkinson, JA;Sadler, PJ
通讯作者：
Sadler, PJ