Changes in Ovarian β-Adrenergic Receptors During the Estrous Cycle of the Rat
Changes in Ovarian β-Adrenergic Receptors During the Estrous Cycle of the Rat
复制标题
大鼠发情周期卵巢β-肾上腺素能受体的变化
DOI：
10.1095/biolreprod24.2.245
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发表时间：
1981
影响因子：
3.6
通讯作者：
A. W. Jordan
中科院分区：
文献类型：
--
作者：
A. W. Jordan
对[3 Hi-二氢阿普洛尔与大鼠卵巢膜结合的斯卡查德图分析表明，大鼠卵巢含有一类特异性、高亲和力β-肾上腺素能受体，这些受体在动情周期期间变化显着。受体浓度在发情前期最高，在发情早晨降至发情前期水平的50%(P<0.001)，然后在发情后期和发情间期增加至发情前期水平。动情周期期间受体亲和力没有变化(KD=2.2±0.1 X i0 M)。这些结果表明卵巢功能可能直接受到神经或肾上腺来源的儿茶酚胺的影响。
Scatchard plot analyses of [3 Hi-dihydroalprenolol binding to rat ovarian membranes revealed that the rat ovary contains a single class of specific, high affinity p-adrenergic receptors which vary significantly during the estrous cycle. Receptor concentrations are highest during proestrus, fall to 50% of proestrus levels in the morning of estrus(P< 0.001), then increase to nar proestrus levels during metestrus and diestrus. There is no change in receptor affinity during the estrous cycle (KD= 2.2±0.1 X i0 M). These results indicate that ovarian function may be influenced directly by catecholamines of either a neural or adrenal origin.