Meta-analysis on the prevalence of REM sleep behavior disorder symptoms in Parkinson's disease.
Meta-analysis on the prevalence of REM sleep behavior disorder symptoms in Parkinson's disease.
复制标题
帕金森病快速眼动睡眠行为障碍症状患病率的荟萃分析。
DOI：
10.1186/s12883-017-0795-4
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发表时间：
2017-02-04
期刊：
影响因子：
2.6
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Zhang J;Xu CY;Liu J
我们的研究旨在评估与健康控制相比，在新诊断的帕金森氏病的患者中，与健康控制患者相比，在患有新诊断的帕金森病的患者中，选择了某些非运动症状的风险。
使用PubMed，Embed，Web of Science和Cochrane数据库搜索了有关荟萃分析和Cochrane手册的元评论的首选报告（PRISMA）指南。在2016年8月3日之前。符合条件的研究是报道新诊断的PD中RBD症状患病率的研究和置置置信区间（CIS）的合并比值比（ORS）通过随机效力的模型计算出来。
我们确定了八项研究，包括2462例PD患者和3818个健康控制率。 CI 3.60至9.00; p = 0.001）具有现代异质性I2 = 70.5％。 4.52; p <0.00001）和异质性被完全消除（I2 = 0％）。
RBD症状是PD的常见非运动症状，PD患者需要进一步研究RBD的风险。
Our study was aimed to evaluate the risk of a selected non-motor symptom, namely rapid eye movement behavior disorder (RBD) symptoms, among patients with newly diagnosed Parkinson disease compared with health controls. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for meta-analysis and Cochrane manual were followed. Studies on RBD symptoms and PD were searched using PubMed, Embase, Web of Science and Cochrane library databases. All studies were published before August 3rd, 2016. Eligible studies were those that reported a prevalence of RBD symptoms among newly diagnosed PD and health control. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by random-effected models. Heterogeneity across studies was assessed using Cochran Q and I2 statistics. We identified eight studies including 2462 PD patients and 3818 health controls. The overall prevalence of RBD symptoms in PD was 582/2462 (23.6%) compared to 131/3818 (3.4%) in control. And the pooled OR was 5.69 (95% CI 3.60 to 9.00; p = 0.001) with a moderate heterogeneity I2 = 70.5%. After excluding the study of low weight, the overall polled OR was 3.54 (95% CI 2.77 to 4.52; p < 0.00001) and the heterogeneity was completely eliminated (I2 = 0%). RBD symptoms are common non-motor symptoms of PD, and people with PD are at a higher risk of developing RBD. Further studies are needed to understand the natural history of RBD symptoms in PD and its etiological and clinical implications.