Verbal fluency performance in amnestic MCI and older adults with cognitive complaints
Verbal fluency performance in amnestic MCI and older adults with cognitive complaints
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DOI：
10.1016/j.acn.2008.01.005
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发表时间：
2008-05-01
影响因子：
2.6
通讯作者：
Flashman, Laura A.
中科院分区：
文献类型：
--
作者：
Nutter-Upham, Katherine E.;Saykin, Andrew J.;Flashman, Laura A.
在对老年人进行神经心理评估时，定期使用语言流畅性测试，而阿尔茨海默病(AD)患者的语言流畅性障碍是一种常见的发现。然而，现有的研究很少调查神经退行性疾病临床前阶段的语言流利性能力和亚型。我们检测了107名老年人的言语流利性表现，其中有遗忘性轻度认知障碍(MCI，n=37)，认知主诉(CC，n=37)，但神经心理功能正常，以及人口统计学上匹配的健康对照组(HC，n=33)。受试者在字母、语义类别和语义转换约束下完成流利性任务。与认知正常的老年人相比，遗忘型MCI的语音和语义流畅性在统计上(但不是在临床上)都有所降低，这表明语义存储和提取的质量发生了细微的变化。对言语流利性的基本结构的研究发现两个因素：转换(包括转换和转换任务)和产出(包括字母、类别和动作命名任务)，这两个因素都将MCI和HC区分开来，尽管程度不同。相关研究结果进一步表明，所有流利性任务都在一定程度上涉及执行控制，而那些增加了执行成分(即转换和转移)的任务对语义知识的依赖程度较低。总体而言，我们的发现强调了在针对临床前痴呆人群的评估单元中包括多个语言流利性测试的重要性，并表明个人的流利性任务可能会利用特定的认知过程。(C)2008年国家神经心理学学会。爱思唯尔有限公司出版。保留所有权利。
Verbal fluency tests are employed regularly during neuropsychological assessments of older adults, and deficits are a common finding in patients with Alzheimer's disease (AD). Little extant research, however, has investigated verbal fluency ability and subtypes in preclinical stages of neurodegenerative disease. We examined verbal fluency performance in 107 older adults with amnestic mild cognitive impairment (MCI, n = 37), cognitive complaints (CC, n = 37) despite intact neuropsychological functioning, and demographically matched healthy controls (HC, n = 33). Participants completed fluency tasks with letter, semantic category, and semantic switching constraints. Both phonemic and semantic fluency were statistically (but not clinically) reduced in amnestic MCI relative to cognitively intact older adults, indicating subtle changes in the quality of the semantic store and retrieval slowing. Investigation of the underlying constructs of verbal fluency yielded two factors: Switching (including switching and shifting tasks) and Production (including letter, category, and action naming tasks), and both factors discriminated MCI from HC albeit to different degrees. Correlational findings further suggested that all fluency tasks involved executive control to some degree, while those with an added executive component (i.e., switching and shifting) were less dependent on semantic knowledge. Overall, our findings highlight the importance of including multiple verbal fluency tests in assessment batteries targeting preclinical dementia populations and suggest that individual fluency tasks may tap specific cognitive processes. (C) 2008 National Academy of Neuropsychology. Published by Elsevier Ltd. All rights reserved.