Intra-Arterial Cis-Platinum Infusion with Sodium Thiosulfate Protection and Angiotensin II Induced Hypertension for Treatment of Hepatocellular Carcinoma
Intra-Arterial Cis-Platinum Infusion with Sodium Thiosulfate Protection and Angiotensin II Induced Hypertension for Treatment of Hepatocellular Carcinoma
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动脉内顺铂输注联合硫代硫酸钠保护和血管紧张素 II 诱导的高血压治疗肝细胞癌
DOI：
10.1177/028418518802900211
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发表时间：
1988
期刊：
影响因子：
1.3
通讯作者：
S. Shinohara
中科院分区：
文献类型：
--
作者：
S. Onohara;H. Kobayashi;Y. Itoh;S. Shinohara
33例肝癌患者肝动脉灌注顺式二胺氯铂II （CDDP, 52 ~ 169 mg/m2）与血管紧张素II （1.5 ~ 10 μg/min）混合。同时静脉注射硫代硫酸钠（10-50 g），以降低CDDP的全身毒性。18例患者（55%）肿瘤缩小50%以上。4例患者（12%）达到完全缓解。18例患者血清甲胎蛋白（AFP）水平超过200 ng/ml的患者中，有10例患者血清甲胎蛋白（AFP）水平下降超过75%。根据Kaplan-Meier方法，一年生存率估计为61%。在近90%的治疗中，消化系统症状（恶心、呕吐）轻微或不存在。少数表现为消化性溃疡和腹痛。没有观察到实验室数据的严重变化。肝细胞癌患者大剂量动脉输注CDDP、血管紧张素和静脉注射硫代硫酸钠具有良好的耐受性和有效的治疗效果。
Cis-diamminedichloroplatinum II (CDDP; 52–169 mg/m2) mixed with angiotensin II (1.5–10 μg/min) was infused into the hepatic artery in 33 patients with hepatocellular carcinoma. Simultaneously, sodium thiosulfate (10–50 g) was administered intravenously in order to reduce the systemic toxicity of CDDP. Over 50 per cent reduction in tumor size was obtained in 18 patients (55%). Complete response was achieved in 4 patients (12%). Serum alpha-fetoprotein (AFP) levels decreased by more than 75 per cent in 10 of 18 patients in whom the previous AFP level was more than 200 ng/ml. The one year survival rate was estimated at 61 per cent by the Kaplan-Meier method. Alimentary symptoms (nausea, vomiting) were mild or non-existent in nearly 90 per cent of treatments. Peptic ulcer and abdominal pain were manifested in small numbers. Severe changes in the laboratory data were not observed. High dosage arterial infusion of CDDP and angiotensin II and intravenous injection of sodium thiosulfate was well tolerated and gave effective therapy in hepatocellular carcinoma.